ALK protein expression in pulmonary adenocarcinoma of Tunisian patients

Arfaoui, A.; Blel, Ahlem; Aloui, Raoudha; Fatnassi, Ghaya; Ammar, Jihane Ben; Znaidi, Nadia; Zidi, Y; Boudaya, Mohamed Sadok; Aouina, H.; Rommani, Soumaya Rammeh

doi:10.1080/15321819.2017.1319860

Cited by 2 publications

(4 citation statements)

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“…23,24 However, the rate is lower than those of 7.1% and 7.8% recorded in Spain and the USA, respectively, 19,20 as well as rates of 5% and 9% in two earlier Tunisian studies. 25,26 In line with most previous reports 5, [21][22][23][24]34 we found that ALKpositive patients were significantly younger than those with ALK-negative tumors.…”

Section: Discussionsupporting

confidence: 90%

“… 23 , 24 However, the rate is lower than those of 7.1% and 7.8% recorded in Spain and the USA, respectively, 19 , 20 as well as rates of 5% and 9% in two earlier Tunisian studies. 25 , 26…”

Section: Discussionmentioning

confidence: 99%

“…A review of the available literature revealed some variation of ALK rearrangements in NSCLC based on studies in White, Asian, and African populations. 5,[19][20][21][22][23][24][25][26][27] Nevertheless, less is known about the Middle East population. This study examined the frequency of ALK rearrangement in a group of Jordanian patients with NSCLC and compared IHC and FISH for detecting ALK gene rearrangement.…”

Section: Introductionmentioning

confidence: 99%

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Anaplastic lymphoma kinase rearrangements in patients with non-small cell lung cancer in Jordan

2022

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Objective Anaplastic lymphoma kinase ( ALK) rearrangement is an important oncogenic driver in some non-small cell lung cancers (NSCLC). Treatment with ALK tyrosine kinase inhibitors improves survival. The availability of diagnostic immunohistochemistry (IHC) has led to a paradigm shift in ALK testing. This study examined the prevalence of ALK rearrangement in Jordanian patients with NSCLC and compared the results of IHC and fluorescence in situ hybridization (FISH) for detecting ALK rearrangement. Methods This retrospective study on 449 patients with NSCLC treated at the King Hussein Cancer Center in Jordan tested biopsy samples for ALK rearrangement using FISH and/or IHC (D5F3) between 2018 and 2020. Results Eighteen patients (4%) had ALK-positive NSCLC. The calculated sensitivity and specificity of ALK immunostaining compared with FISH were 87.5% and 96%, respectively. ALK-positive patients were significantly younger than their ALK-negative counterparts, and women were three times more likely to carry ALK rearrangement than men. ALK rearrangement was significantly associated with smoking history, with most ALK-positive patients being non-smokers, former smokers, or light smokers. Conclusions IHC is a reasonable alternative to FISH for ALK testing with advantages in terms of robustness, turnaround times, and cost-effectiveness.

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Section: Discussionsupporting

confidence: 90%

“… 23 , 24 However, the rate is lower than those of 7.1% and 7.8% recorded in Spain and the USA, respectively, 19 , 20 as well as rates of 5% and 9% in two earlier Tunisian studies. 25 , 26…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Anaplastic lymphoma kinase rearrangements in patients with non-small cell lung cancer in Jordan

2022

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“…The frequency that we found falls globally between the frequencies reported in whites and those reported in Asians [9][10][11][12][13][14]. However, it's lower than the frequency found in two previous Tunisian studies that reported an ALK rearrangement frequency of 5.2 and 9.09%, respectively [15,16] (Table 4).…”

Section: Discussioncontrasting

confidence: 60%

Frequency of anaplastic lymphoma kinase rearrangements in Moroccan patients with non small cell lung cancer: a multi-institutional national retrospective study

Yacoubi

Sow

Kettani³

et al. 2020

BMC Cancer

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Background: Anaplastic lymphoma kinase (ALK) rearrangement is a predictive factor of response to ALK inhibitors in non small cell lung cancer (NSCLC). The prevalence of ALK rearrangements is well known in Whites and Asians. However, data identifying the frequency of this rearrangement in Moroccan and North African population are lacking. The objective of this study is to report the frequency of ALK rearrangement in a group of Moroccan patients with NSCLC. Methods: A retrospective study was performed enrolling 120 Moroccan patients with NSCLC whose biopsy samples were tested for ALK rearrangement in order to identify the frequency of ALK rearrangement and its potential association with selected variables. The ALK testing was established using fluorescent in situ hybridization (FISH) or immunohistochemistry (IHC). Results: The frequency of ALK rearrangement was 4.2% (5/120). All positive cases were males with advanced adenocarcinoma. ALK rearrangements prevalence was significantly higher in older patients. Conclusions: The frequency of ALK rearrangements among the Moroccan population tends to correlate with the average frequency reported worldwide, with some specific features. Further prospective studies with larger patients' numbers are needed to verify these findings.

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ALK protein expression in pulmonary adenocarcinoma of Tunisian patients

Abstract: The frequency of positive ALK expression based on immunohistochemistry in our series was similar to that reported in the world literature.

Cited by 2 publications

References 32 publications

Anaplastic lymphoma kinase rearrangements in patients with non-small cell lung cancer in Jordan

Anaplastic lymphoma kinase rearrangements in patients with non-small cell lung cancer in Jordan

Frequency of anaplastic lymphoma kinase rearrangements in Moroccan patients with non small cell lung cancer: a multi-institutional national retrospective study

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