Alkali-resistant Cooley's anemia hemoglobin is different from alkali-resistant fetal hemoglobin

A Critical Review of Human Haemoglobin Variants

“…End group analyses have been carried out by Schapira and Dreyfus (1954), Masri and Singer (1955), Huisman and Drinkwaard (1955), Schroeder and Matsuda (1958), and Huisman and Dozy (1956). Complete aminoacid analyses are described by Rossi-Fanelli et al (1954), Dustin et al (1954, van der Schaaf and Huisman (1955a), Huisman et al (1955b), and Stein et al (1957); the globin alone has been examined by Dustin et al (1954) and Perosa (1950). Dustin et al (1954), Huisman et al (1955b, and van der Linden (1950) discuss the isoleucine content, which is the greatest structural difference between Hb-F and other haemoglobins.…”

Further Cases of Cooley’s Anaemia in Indonesia

“…No satisfactory answer has been found up to now. Already there are workers who are of the opinion that the alkali-resistant haemoglobin found in C o o ley 's anaemia is not identical with the alkali-resistant haemoglobin in the newborn (10,2,3 n iq u e s w ill lead to a fu rth e r d iffe re n tia tio n o f this C o o l e y 's a n a e m ia g ro u p .…”

Differences between Alkali Resistant Haemoglobin Fractions of Cooley’s Anaemia, of Fetal Blood and of Sickle Cell Anaemia

“…By free electrophoresis in acid cacodylate buffer D e r r ie u a nd R ey naud (2) found a different behaviour of fetal haemoglobin and the alkali resistant haemoglobin fraction of C o o l e y 's anaemia. P erosa a nd Bini (4) …”