Alkaline Intraoesophageal pH and Gastro-oesophageal Reflux in Patients with Peptic Oesophagitis

Penagini, Roberto; Yuen, Henry Jeffrey; Misiewicz, J. J.; Bianchi, P.

doi:10.3109/00365528809093931

Cited by 18 publications

(2 citation statements)

References 10 publications

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“…9 While pH probes were successfully developed to accurately monitor acid reflux, measurement of bile reflux has been difficult. Indirect evidence of increased bile in the stomach with aspiration studies 10 or dual pH monitoring 11 showed an association with esophagitis and Barretts. Presence of bile in the esophagus has also been demonstrated by using prolonged esophageal aspiration studies.…”

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confidence: 97%

Bile in the Esophagus—Model for a Bile Acid Biosensor

Nehra

2010

Journal of Gastrointestinal Surgery

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Acid and bile acids form important constituents of the refluxed substances in patients who suffer from gastroesophageal reflux disease. Whilst 24h ambulatory pH monitoring using antimony or glass pH electrodes measures acid levels 5 cm above the gastroesophageal junction, there are no reliable methods of measuring other constituents of duodenal juices such as bile acids. Past studies in detection of bile acids have included esophageal aspiration studies with detection of bile acids with HPLC or indirect methods using fiber-optic bile sensor "Bilitec" to detect bilirubin in the bile. These methods have either been impracticable or unreliable for routine and accurate measurement of bile acid. More recently, impedance technology has been used to define "weakly" acid or alkaline reflux. There are many potential applications of biosensors of various types, and it is envisaged that a biosensor specific for bile acid would be a more practical tool for routine measurement. This paper looks at a model for development of a biosensor for bile acid based on molecular imprinted polymers.

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confidence: 97%

Bile in the Esophagus—Model for a Bile Acid Biosensor

Nehra

2010

Journal of Gastrointestinal Surgery

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“…Consequently, a change of 1 pH unit is the most that can be expe cted. Although accepted as a possibility (1,3), it is still an open question to what extent alkaline GER really causes a pathologic condition. It cannot be excluded that periods of alkaline pH in the esophagus, without a simultaneous alkaline pH recorded below the cardia, are of salivary origin , Simultaneous recording of gastric and esophageal pH was therefore pro-posed to detect alkaline reflux.…”

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confidence: 99%

Alkaline Gastroesophageal Reflux in Infancy

Vandenplas,

Loeb

1991

J. pediatr. gastroenterol. nutr.

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SummaryAlkaline gastroesophageal reflux is a rare disorder, although it has been suggested as a cause of esoph‐agitis. However, up to now, there exists no unequivocally accepted diagnostic method for alkaline reflux that can be routinely applied. “Normal ranges” of episodes of pH greater than 7.0–7.5 in asymptomatic as well as in symptomatic infants are proposed. In the asymptomatic infants (n = 83), the mean percentage of time the pH was > 7.0 was 1.3 ± 2.6, and the number of episodes in 24 h with a pH > 7.0 was 10.4 ± 16.4. In the symptomatic group (n = 60), including infants with chronic vomiting, the mean percentage of time the pH was greater than 7.0 was 0.15 ± 0.5, and the number of episodes with a pH greater than 7.0 was 2.8 ± 5.5. In all but six infants the percentage of time the pH was greater than 7.5 was less than 0.1. In three of four of these infants (endoscopy was refused by two parents) whose conditions exceeded the cut‐off limits, there was a histologically proven esophagitis. To evaluate the proposed “normal” ranges for episodes of pH greater than 7.0 and 7.5, 200 symptomatic children were included in a prospective study. Symptoms were repetitive vomiting (n = 110), excessive crying (n = 53), and chronic respiratory disease (n = 37). Esophagoscopy was performed in 18 babies (9%) because pH monitoring data exceeded the proposed limits for the percentage of time the pH was greater than 7.0. The percentage of time the pH was greater than 7.5 was increased in 13 (6.5%) infants. Esophagitis was proven by histologic study in nine infants (4.5% of the total group): in three of nine, reflux was “mixed” (acid and alkaline); in six of nine, reflux was alkaline. If data exceed the proposed limits of episodes with a pH greater than 7.5, alkaline reflux is likely to occur and should be further investigated (e.g., by double esophageal or combined gastric and esophageal pH monitoring) to confirm the diagnosis of alkaline reflux.

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Duodenogastroesophageal Reflux

Sifrim

Penagini

2021

The Esophagus

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Alkaline Intraoesophageal pH and Gastro-oesophageal Reflux in Patients with Peptic Oesophagitis

Cited by 18 publications

References 10 publications

Bile in the Esophagus—Model for a Bile Acid Biosensor

Bile in the Esophagus—Model for a Bile Acid Biosensor

Alkaline Gastroesophageal Reflux in Infancy

Duodenogastroesophageal Reflux

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