Alkaline oxidization can increase the in vitro antiparasitic activity of proanthocyanidin-rich plant extracts against Ascaris suum

Imran, Iqbal Bin; Engström, Marica T.; Karonen, Maarit; Williams, Andrew R.; Salminen, Juha‐Pekka

doi:10.1016/j.exppara.2023.108493

Cited by 1 publication

(1 citation statement)

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“…However, the ease of access to some phytochemicals (natural products from plants) and their use in the form of extracts and as nutraceuticals (food and/or food components with potential medicinal use) without laborious pharmaceutical syntheses have attracted the attention of scientists for the therapeutic use of natural products [ 103 ]. Many biological activities associated with natural products have already been reported, such as antibiotic [ 102 ], antiparasitic [ 105 ], antifungal [ 106 ], antioxidant [ 107 ], anti-inflammatory [ 108 ], antitumorigenic [ 109 ], and hepatoprotective activities [ 110 ]. Thus, it is an important direct and indirect source for the development of new drugs.…”

Section: Targeting Oxidative Stress With Natural Compounds In Liver P...mentioning

confidence: 99%

Targeting Oxidative Stress with Polyphenols to Fight Liver Diseases

et al. 2023

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Reactive oxygen species (ROS) are important second messengers in many metabolic processes and signaling pathways. Disruption of the balance between ROS generation and antioxidant defenses results in the overproduction of ROS and subsequent oxidative damage to biomolecules and cellular components that disturb cellular function. Oxidative stress contributes to the initiation and progression of many liver pathologies such as ischemia-reperfusion injury (LIRI), non-alcoholic fatty liver disease (NAFLD), and hepatocellular carcinoma (HCC). Therefore, controlling ROS production is an attractive therapeutic strategy in relation to their treatment. In recent years, increasing evidence has supported the therapeutic effects of polyphenols on liver injury via the regulation of ROS levels. In the current review, we summarize the effects of polyphenols, such as quercetin, resveratrol, and curcumin, on oxidative damage during conditions that induce liver injury, such as LIRI, NAFLD, and HCC.

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