Alkaline Phosphatase and Risk of Stroke Among Japanese: The Circulatory Risk in Communities Study (CIRCS)

Shimizu, Yūji; Imano, Hironori; Ohira, Tetsuya; Kitamura, Akihiko; Kiyama, Masahiko; Okada, Takeo; Ishikawa, Yoshinori; Satō, Takashi; Yamagishi, Kazumasa; Tanigawa, Takeshi; Iso, Hiroyasu

doi:10.1016/j.jstrokecerebrovasdis.2012.06.009

Cited by 43 publications

(69 citation statements)

References 38 publications

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“…GGT has attracted considerable attention as a predictor of metabolic syndrome, insulin resistance, cardiovascular disease, stroke, and cancer [2][3][4][5][6][7]. Furthermore, elevated GGT is associated with higher allcause mortality [8,9].…”

Section: Introductionmentioning

confidence: 99%

Serum gamma-glutamyltransferase level is associated with serum superoxide dismutase activity and metabolic syndrome in a Japanese population

et al. 2011

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Section: Introductionmentioning

confidence: 99%

Serum gamma-glutamyltransferase level is associated with serum superoxide dismutase activity and metabolic syndrome in a Japanese population

et al. 2011

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“…Consistent linear or U-shaped positive correlations have been observed between circulating (plasma or serum) AP activity and increased risks of various diseases, including hypertension, stroke and CVD [39][40][41]. This may not be surprising because circulating AP may be a marker of inflammation [11].…”

Section: Recent Epidemiological Data On the Effects Of Dairy Productsmentioning

confidence: 78%

Dairy products and the French paradox: Could alkaline phosphatases play a role?

Lallès

2016

Medical Hypotheses

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“…In an interesting study [13] the authors prospectively evaluated the incidence of stroke based on levels of serum ALP. There was a J-shaped association and not only people with higher levels of serum ALP were associated with stroke but those with lower levels also.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, there have been studies showing significance of increased serum ALP and phosphate in stroke population also [12,13]. These are biochemical parameters which can be easily obtained in most of the centres and cost effective, even in developing countries like India.…”

Section: Introductionmentioning

confidence: 99%

Increased Serum Alkaline Phosphatase and Serum Phosphate as Predictors of Mortality after Stroke

2014

JCDR

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Context: Serum Alkaline phosphatase (ALP) & phosphate are considered to be indicators of vascular calcification. Link between bone metabolism, vascular calcification, cardiovascular events have been well studied in chronic kidney disease and ischemic heart disease.Aims: To determine that increased serum phosphate and alkaline phosphatase are predictors of mortality rates and recurrent vascular events in stroke. Materials and Methods:Sixty patients admitted with acute stroke (ischemic & haemorrhagic) were included in the study. Their baseline clinical characteristics and biochemical parameters including serum ALP and phosphate were noted. All patients were followed up for a period of one year. The all-cause mortality, the mortality due to cardiovascular events and recurrent vascular events without death were noted during the follow up. Statistical analyses were done to look for any correlation between mortality and baseline levels of serum ALP and phosphate.Results: Of the 60 patients, 8 (13.3%) patients were lost for follow up. Fourteen (26.9%) patients died; of which 12 deaths were due to vascular causes and 2 deaths were due to non vascular causes. Increasing levels of serum ALP and phosphate correlated with all cause mortality and recurrent vascular events without death Conclusion: Serum ALP and phosphate prove to be cost effective prognostic indicator of mortality and recurrent vascular events in stroke. This finding has to be confirmed with studies including larger population. Further research on ALP inhibitors, Vitamin D analogues and phosphate binders to improve mortality in stroke population can be encouraged.

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Alkaline Phosphatase and Risk of Stroke Among Japanese: The Circulatory Risk in Communities Study (CIRCS)

Cited by 43 publications

References 38 publications

Serum gamma-glutamyltransferase level is associated with serum superoxide dismutase activity and metabolic syndrome in a Japanese population

Serum gamma-glutamyltransferase level is associated with serum superoxide dismutase activity and metabolic syndrome in a Japanese population

Dairy products and the French paradox: Could alkaline phosphatases play a role?

Increased Serum Alkaline Phosphatase and Serum Phosphate as Predictors of Mortality after Stroke

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