Alkaline phosphatase isoenzymes in children with respiratory disease

Transient Benign Hyperphophatasemia

“…Twenty‐six pertinent reports were found in the references of the mentioned reports. Hence, a total of 142 reports were included in the final analysis (9–150) (references 51–150 are online only: http://links.lww.com/MPG/A215): 84 in English (9–92), 8 in French (93–100), 5 in German (101–105), 18 in Italian (106–123), 1 in Portuguese (124), and 26 in Spanish (125–150). They had been reported from Italy (N = 22), Spain (N = 21), the United States (N = 19), Great Britain (N = 14), Germany (N = 11), France (N = 9), Czech Republic (N = 7), Argentine (N = 6), Belgium (N = 3), Canada (N = 3), Japan (N = 3), Australia (N = 2), Brazil (N = 2), Croatia (N = 2), Denmark (N = 2), Israel (N = 2), Ireland (N = 2), Scotland (N = 2), Switzerland (N = 2), Venezuela (N = 2), Finland (N = 1), Greece (N = 1), China (N = 1), Poland (N = 1), Sweden (N = 1), and Turkey (N = 1).…”

“…In the 641 subjects (87%) without any underlying chronic condition (male:female ratio 1.1:1.0; not significant), the initial determination of the alkaline phosphatase level was made either in the context of a checkup or in the context of likely infectious illnesses (Table 1). Transient benign hyperphosphatasemia patients with a chronic underlying condition were significantly older than subjects without any underlying chronic condition by 9 months (26 vs 17 [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29][30] months; P < 0.0005). On the contrary, the highest alkaline phosphatase ratio (7.9 [4.3-17] vs 9.8 [4.7-18]) and the duration of the elevation of the alkaline phosphatase level (10 [7-14] vs 10 [5-18] weeks) were similar in subjects with and without any underlying condition.…”

Hepatitis during respiratory syncytial virus infection – a case report

“…In patients with BTH, ALP may have 10-fold increase. In our previous study, values of ALP were in the range 528–5622 U/L ( 22 ), and Dori et al . have shown ALP values to be in the range 805–8619 U/L ( 24 ).…”

“…Benign transient hyperphosphatasemia (BTH) may appear during the season of viral infections ( 19 – 21 ). Our previous investigation revealed that both, bacterial and viral infections may be a direct cause of BTH ( 22 ). In that study, children with bacterial respiratory infection had higher ALP values than children with viral infections.…”