Alkalinizing Agents for the Treatment of Cardiac Arrest

Weil, Max Harry; Kette, Fulvio; Gazmuri, Raúl J; Rackow, Eric C.

doi:10.1007/978-1-4614-7542-2_9

Hypoxia, Metabolic Acidosis, and the Circulation 1992

DOI: 10.1007/978-1-4614-7542-2_9

|View full text |Cite

Alkalinizing Agents for the Treatment of Cardiac Arrest

Max Harry Weil¹,

Fulvio Kette²,

Raúl J Gazmuri³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1993

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Maintenance of high extracellular pH does not influence cell pH or metabolism in submerged anoxic bullfrogs

Wasser¹,

Jackson²,

Chang³

et al. 1993

J. Exp. Zool.

View full text Add to dashboard Cite

We compared extracellular and intracellular acid-base states in paralyzed bullfrogs subjected to 4 h of anoxic submergence at 15 degrees C with or without maintenance of extracellular pH at preanoxic levels by bicarbonate infusion. We also assessed anaerobic metabolism under these conditions by measuring tissue lactate and glycogen concentrations in liver, heart, and skeletal muscle. Although bicarbonate infusion resulted in a significantly higher arterial blood pH (pHe) than saline infusion, intracellular pH (pHi) of heart and skeletal muscle, as determined by the DMO equilibration technique, were not significantly different after 4 h of anoxia. We were also unable to demonstrate any differences in anaerobic metabolic rate, since both tissue lactate accumulation and glycogen depletion were identical in bicarbonate- and saline-infused frogs in the tissues studied. We conclude that (1) alterations in the extracellular acid-base state by bicarbonate infusion are not necessarily reflected in the intracellular compartment, perhaps due to powerful intracellular buffering processes, and (2) maintenance of an alkaline extracellular pH during anoxia in bullfrogs does not influence the anaerobic metabolic rate. We could not, however, rule out a possible role for intracellular pH in regulating anaerobic metabolism during anoxia in frogs.

show abstract

Maintenance of high extracellular pH does not influence cell pH or metabolism in submerged anoxic bullfrogs

Wasser¹,

Jackson²,

Chang³

et al. 1993

J. Exp. Zool.

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Alkalinizing Agents for the Treatment of Cardiac Arrest

Cited by 1 publication

References 88 publications

Maintenance of high extracellular pH does not influence cell pH or metabolism in submerged anoxic bullfrogs

Maintenance of high extracellular pH does not influence cell pH or metabolism in submerged anoxic bullfrogs

Contact Info

Product

Resources

About