Alkaloid-metabolites from the mangrove-derived fungus Penicillium robsamsonii HNNU0006

Wang, Jing-Wen; Liu, Yi-Yi; Chen, Guang-Ying; Zheng, Cai-Juan; Nong, Xu-Hua

doi:10.1016/j.fitote.2024.105906

Fitoterapia

2024

DOI: 10.1016/j.fitote.2024.105906

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Alkaloid-metabolites from the mangrove-derived fungus Penicillium robsamsonii HNNU0006

Jing-Wen Wang,

Yi-Yi Liu,

Guang-Ying Chen

et al.

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2024

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Cited by 3 publications

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Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041

Li,

Liu,

Lin

et al. 2024

Journal of Asian Natural Products Research

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Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041

Li,

Liu,

Lin

et al. 2024

Journal of Asian Natural Products Research

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New Bioactive Polyketides from the Mangrove-Derived Fungus Penicillium sp. SCSIO 41411

Chen,

Cai,

Xia

et al. 2024

Marine Drugs

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Three new polyketides, including three ester derivatives (1, 3, and 5) and a new natural product, which was a benzoquinone derivative, embelin A (4), together with nine known ones (2 and 6–13), were isolated from the mangrove-derived fungus Penicillium sp. SCSIO 41411. Their structures were determined by detailed NMR and MS spectroscopic analyses. The X-ray single-crystal diffraction analysis of 4 was described for the first time. Compound 9 displayed obvious inhibition against PDE4 with an inhibitory ratio of 40.78% at 10 μM. Compound 12 showed DPPH radical scavenging activity, with an EC50 of 16.21 µg/mL, compared to the positive control (ascorbic acid, EC50, 11.22 µg/mL). Furthermore, compound 4 exhibited cytotoxicity against PC-3 and LNCaP with IC50 values of 18.69 and 31.62 µM, respectively.

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Secondary Metabolites from the Mangrove Ecosystem-Derived Fungi Penicillium spp.: Chemical Diversity and Biological Activity

Zhou,

Cai,

Wang

et al. 2024

Marine Drugs

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Mangrove ecosystems have attracted widespread attention because of their high salinity, muddy or sandy soil, and low pH, as well as being partly anoxic and periodically soaked by tides. Mangrove plants, soil, or sediment-derived fungi, especially the Penicillium species, possess unique metabolic pathways to produce secondary metabolites with novel structures and potent biological activities. This paper reviews the structural diversity and biological activity of secondary metabolites isolated from mangrove ecosystem-derived Penicillium species over the past 5 years (January 2020–October 2024), and 417 natural products (including 170 new compounds, among which 32 new compounds were separated under the guidance of molecular networking and the OSMAC approach) are described. The structures were divided into six major categories, including alkaloids, polyketides, terpenoids, benzene derivatives, steroids, and other classes. Among these natural products, the plausible biosynthetic pathways of 37 compounds were also proposed; 11 compounds have novel skeleton structures, and 26 compounds contain halogen atoms. A total of 126 compounds showed biological activities, such as cytotoxic, antifungal, antibacterial, anti-inflammatory, and α-glucosidase-inhibitory activities, and 11 compounds exhibited diverse biological activities. These new secondary metabolites with novel structures and potent bioactivities will continue to guide the separation or synthesis of structurally novel and biologically active compounds and will offer leading compounds for the development and innovation of pharmaceuticals and pesticides.

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Alkaloid-metabolites from the mangrove-derived fungus Penicillium robsamsonii HNNU0006

Cited by 3 publications

References 21 publications

Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041

Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041

New Bioactive Polyketides from the Mangrove-Derived Fungus Penicillium sp. SCSIO 41411

Secondary Metabolites from the Mangrove Ecosystem-Derived Fungi Penicillium spp.: Chemical Diversity and Biological Activity

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