Alkaloids and Coumarins of Casimiroa edulis

Plant use in the medicinal practices known as “strict diets” in Chazuta valley (Peruvian Amazon)

“…In addition n-hentriacontane has also shown analgesic and diuretic activities (Meyre-Silva et al, 1998;Rizvi et al, 1985). Moreover, rouremin (glycoside) isolated in R. minor has presented antimalarial activity (Bero et al, 2009;Chevrier et al, 1986;Grosvenor et al, 1995;He et al, 2006;Kalegari, 2009).…”

“…Various compounds isolated from Ruellia species have demonstrated antinflammatory, antimicrobial and CNS depressant activities (Ahmad et al, 1990;Costa De Pasquale et al, 1985;Kalashnikova and Gerashchenko, 1974;Leiderman et al, 1996;Misra et al, 1997;Rizvi et al, 1985;Salah, 1999). Furthermore, n-hentriacontane has been also found in Ruellia sp.…”

New alkaloids from Casimiroa edulis fruits and their pharmacological activity

“…Earlier, extensive studies have been carried out on the isolation and identification of the chemical constituents of the bark, seeds, and root of Casimiroa edulis [4][5][6]. The isolated compounds include casimiroedine and dimethylhistamine [5], Nα,Nα-dimethylhistamine [6], zapoterin, imidazole [7], and 2-quinolinone, and 4-quinolones [8]. The aqueous extract of Casimiroa edulis leaves has antiinflammatory and diuretic activities [8].…”

Central nervous system activity of the hydroalcoholic extract of Casimiroa edulis in rats and mice

“…The ancient Nahuatl name for the fruits, "cochitzápotl", can be translated in "sleepy zapote" or "sleep-producing zapote" (Lozoya and Enríquez, 1981). The decoction of the leaves and seeds from this plant has been widely used to treat anxiety, insomnia and hypertension in Mexican traditional medicine (Martinez, 1951;Rizvi et al, 1985;Vidrio and Magos, 1991;Hernández, 1993;Garzón-de la Mora et al, 1999). Several investigations have proposed that this plant possess cardiovascular and central nervous system pharmacological effects, producing peripheral vaso-relaxing activity as well as hypnotic and sedative effects.…”