Alkaloids and Isoprenoids Modification by Copper(I)-Catalyzed Huisgen 1,3-Dipolar Cycloaddition (Click Chemistry): Toward New Functions and Molecular Architectures

Reactive Plasticizers Covalently Linked to Glycidyl Azide Polymer via Catalyst‐Free Huisgen Azide‐Alkyne Cycloaddition

“…The "Click" chemistry was introduced by Sharpless and coworkers in 2001. The Huisgen 1,3-dipolar cycloaddition between an azide and a terminal alkyne is the best way to convert azide groups into triazoles [17][18][19][20].…”

Design, combinatorial synthesis and biological evaluations of novel 3-amino-1′-((1-aryl-1 H -1,2,3-triazol-5-yl)methyl)-2′-oxospiro[benzo[ a ] pyrano[2,3- c ]phenazine-1,3′-indoline]-2-carbonitrile antitumor hybrid molecules

“…Click chemistry, mainly the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), offers a robust approach to construct 1,2,3-triazole moieties, which are attractive connecting units because they are stable to metabolic degradation and capable of hydrogen bonding, which can well bind biomolecular targets and improve compounds' solubility [25]. The rapid construction and screening of focused combinatorial fragment libraries using CuAAC click chemistry is a highly efficient way for establishing structure-activity relationship (SAR) and for discovering bioactive molecules [26,27].…”

Iridium‐Catalyzed Hydroxyl‐Enabled Cycloaddition of Azides and Alkynes

“…Moreover, the biological interesting molecules such as coumarin, glucose, cholesterol, and L-phenylalanine ester tethered azides were also employed in this process to deliver the corresponding triazoles (3 z, 3 a', 3 b' and 3 c'), demonstrating the utility in natural products derivatization and medicinal chemistry. [16] Interestingly, the solid azide 2 n was subject to the cycloaddition in water, and the triazole 3 z could be furnished in 64% yield (see Supporting Information).…”