Alkaloids and volatile constituents from Duguetia flagellaris

Fechine, Yvana; Navarro, Vanessa R.; Cunha, Emídio Vasconcelos Leitão da; Silva, Marcelo S.; Maia, José Guilherme S.; Barbosa-Filho, José Maria

doi:10.1016/s0305-1978(01)00090-4

Cited by 24 publications

(15 citation statements)

References 12 publications

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“…Alkaloids have also been isolated from other species of the Duguetia genus and are common in the Annonaceae family (Leboeuf et al 1980). It is widely known that alkaloids present cytotoxic activity and also potent topoisomerase II inhibition effect (Leboeuf et al 1980, Woo et al 1999, Pereira et al 2003, Fechine et al 2002, Maia et al 2006, Muhammad et al 2001, Tempone et al 2005. Thus, the cytotoxic activity found in this study can be attributed, at least partially, to the action of alkaloids.…”

Section: Discussionsupporting

confidence: 60%

Assessment of Duguetia furfuracea genotoxic and cytotoxic activity in bacteria and mice

Silva¹,

Vieira²,

Santos³

et al. 2012

An. Acad. Bras. Ciênc.

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Duguetia furfuracea (St. Hil.) Benth & Hook f. (1862), popularly known as "sofre-do-rim-quem-quer" and "araticum-seco", is a shrub of the Annonaceae family that occurs in several regions of Brazil. In folk medicine the infusion of its leaves and twigs is used to treat rheumatism and renal colic, whereas the seed powder is mixed with water to treat pediculosis. Previous studies have described biological activities of this plant with cytotoxic, antitumoral, trypanocidal, leishmanicidal, antiplasmodial and antiprotozoal effects. In the present work, genotoxicity and cytotoxicity of Duguetia furfuracea lyophilized leaf extract were evaluated using the prophage λ induction test (SOS-Inductest) and mouse bone marrow micronucleus test. Our results showed that Duguetia furfuracea lyophilized leaf extract did not present an increase either in the induction of prophage λ (P>0.05) using the SOS-inductest or in the micronucleated polychromatic erythrocytes (P>0.05) using the micronucleus test, suggesting absence of genotoxicity in both tests. On the other hand, a significant decrease in the number of bacteria, (P<0.05), as well as a significant decrease in the polychromatic erythrocytes and normochromatic erythrocytes ratio, (P<0.05), were observed, showing the cytotoxic action of Duguetia furfuracea lyophilized leaf extract. Thus, Duguetia furfuracea did not present the genotoxic action, but showed a cytotoxic effect in both assays utilized in the present work.

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Section: Discussionsupporting

confidence: 60%

Assessment of Duguetia furfuracea genotoxic and cytotoxic activity in bacteria and mice

Silva¹,

Vieira²,

Santos³

et al. 2012

An. Acad. Bras. Ciênc.

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“…No presente trabalho, apesar da grande variabilidade química observada entre os dois grupos, ou seja, a presença principalmnente de monoterpenos, seguida de sequiterpenos, no perfi l A e, praticamente, uma ausência de monoterpenos no perfi l B, juntamente com o número reduzido de indivíduos avaliados (três), bem como a realização de uma só análise para cada individuo, não nos fornece dados estatisticamente sufi cientes para que se possa discutir a existência de quimiotipos na espécie (Grayer et al, 1996;Rohloff et (Maia et al, 2006, Maia et al, 2005, Lago et al, 2003Fechine et al, 2002). Tem-se sugerido a predominância de constituintes oxigenados nos óleos essenciais de espécies de Annonaceae coletadas na região amazônica, quando comparada com as do cerrado (Lago et al, 2003).…”

Section: Resultsunclassified

Variação química no óleo essencial das folhas de seis indivíduos de Duguetia furfuracea (Annonaceae)

Valter¹,

Alencar²,

Sartori³

et al. 2008

Rev. bras. farmacogn.

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RESUMO:Duguetia furfuracea, Annonaceae, uma invasora de pastagens, é também usada na medicina tradicional em diversos estados no Brasil. Devido à signifi cante diferença de odor entre dois grupos de indivíduos desta planta em um remanescente de cerrado em Campo Grande, Mato Grosso do Sul, seis amostras foram selecionadas de acordo com a intensidade de odor em suas folhas: In-01, In-03 e In-05: odor pronunciado (Perfi l A); In-02, In-04 e In-06: odor fraco ou ausência de odor (Perfi l B). As folhas foram coletadas e submetidas a hidrodestilação para obtenção dos óleos essenciais, os quais foram analisados por CG/EM. Uma boa compatibilidade foi encontrada entre os resultados obtidos por CG/EM e a análise olfativa adotada para as amostras: espécimes odor pronunciado apresentaram uma alta porcentagem de monoterpenos e alguns sesquiterpenos: In-01 ( -felandreno, 42,2%; mirceno, 6,8%; -felandreno, 4,6%); In-03 (terpin-4-ol, 21,6%; sabineno, 17,3%; p-cimeno, 5,6%); In-05 (sabineno, 25,1%; terpin-4-ol, 16,2%; pcimeno, 8,3%). Apenas sesquiterpenos foram encontrados nos espécimes que apresentaram odor fraco ou ausência do mesmo (com constituinte majoritário biciclogermacreno: 21,4%, 24,0%, and 29,1%, respectivamente, para os In-02, In-04 e In-06).Unitermos: Duguetia furfuracea, Annonaceae, óleo volátil.ABSTRACT: "Chemical variability of the essential oil of the leaves from six individuals of Duguetia furfuracea (Annonaceae)". Duguetia furfuracea, Annonaceae, a pasture weed, is also used in folk medicine in several Brazilian states. Because of the signifi cant difference in odor between two groups of this plant in a remnant patch of savanna in Campo Grande county, Mato Grosso do Sul, six samples were selected according to the odor intensity in the leaves (In-01, In-03, and In-05: pronounced odor; In-02, In-04, and In-06: weak odor or its absence). The leaves were collected and subjected to steam distillation for extraction of essential oils, which were analyzed by GC-MS. A good agreement was found between CG/MS results and olfactory evaluation of the samples: specimens exhibiting leaf scent had a high percentage of monoterpenes and some sesquiterpenes, as follows: In-01 ( -phellandrene, 42.2%; myrcene, 6.8%; -phellandrene, 4.6%); In-03 (terpin-4-ol, 21.6%; sabinene, 17.3%; p-cymene, 5.6%); 25.1%; 16.2%; 8.3%). Only sesquiterpenes were found in the specimens having weakly scented or scentless leaves (main constituent bicyclogermacrene: 21.4%, 24.0%, and 29.1%, respectively, for In-02, In-04 and In-06).

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“…pachypodanthine, oliveroline, oliveridine, and duguetine were isolated from Brazilian plant Duguetia flagellaris belonging to Annonaceae (Navarro et al 2001;Fechine et al 2002).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Naturally occurring plant isoquinoline N-oxide alkaloids: Their pharmacological and SAR activities

Dembitsky¹,

Gloriozova

Poroikov

2015

Phytomedicine

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Alkaloids and volatile constituents from Duguetia flagellaris

Cited by 24 publications

References 12 publications

Assessment of Duguetia furfuracea genotoxic and cytotoxic activity in bacteria and mice

Assessment of Duguetia furfuracea genotoxic and cytotoxic activity in bacteria and mice

Variação química no óleo essencial das folhas de seis indivíduos de Duguetia furfuracea (Annonaceae)

Naturally occurring plant isoquinoline N-oxide alkaloids: Their pharmacological and SAR activities

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