Alkaloids from Black Pepper (<i>Piper nigrum</i> L.) Exhibit Anti-Inflammatory Activity in Murine Macrophages by Inhibiting Activation of NF-κB Pathway

Pei, Heying; Xue, Linlin; Tang, Minghai; Tang, Huan; Kuang, Shuang Yuan; Wang, Lun; Ma, Xu; Cai, Xiaoying; Li, Yan; Zhao, Min; Peng, Aihua; Ye, Haoyu; Chen, Lijuan

doi:10.1021/acs.jafc.9b07754

Cited by 60 publications

(39 citation statements)

References 53 publications

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“…The isolated alkaloid from P. nigrum exhibited anti-inflammatory effect in RAW 264.7 cells stimulated by LPS and significant inhibition in iNOS-mediated NO and IL-1β, IL-6, and TNF-α. It also demonstrated anti-inflammatory activity in edema induced by carrageenan (Pei et al, 2020). Reports have confirmed the improvement of ovalbumin-induced nasal epithelial barrier dysfunction in allergic rhinitis mouse model.…”

Section: Piper Nigrum L (Black Pepper)mentioning

confidence: 72%

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

et al. 2021

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The cases of COVID-19 are still increasing day-by-day worldwide, even after a year of its first occurrence in Wuhan city of China. The spreading of SARS-CoV-2 infection is very fast and different from other SARS-CoV infections possibly due to structural differences in S proteins. The patients with severe diseases may die due to acute respiratory distress syndrome (ARDS) caused by systemic inflammatory reactions due to the excessive release of pro-inflammatory cytokines and chemokines by the immune effector cells. In India too, it is spreading very rapidly, although the case fatality rate is below 1.50% (https://www.statista.com), which is markedly less than in other countries, despite the dense population and minimal health infrastructure in rural areas. This may be due to the routine use of many immunomodulator medicinal plants and traditional AYUSH formulations by the Indian people. This communication reviews the AYUSH recommended formulations and their ingredients, routinely used medicinal plants and formulations by Indian population as well as other promising Indian medicinal plants, which can be tested against COVID-19. Special emphasis is placed on Indian medicinal plants reported for antiviral, immunomodulatory and anti-allergic/anti-inflammatory activities and they are categorized for prioritization in research on the basis of earlier reports. The traditional AYUSH medicines currently under clinical trials against COVID-19 are also discussed as well as furtherance of pre-clinical and clinical testing of the potential traditional medicines against COVID-19 and SARS-CoV-2. The results of the clinical studies on AYUSH drugs will guide the policymakers from the AYUSH systems of medicines to maneuver their policies for public health, provide information to the global scientific community and could form a platform for collaborative studies at national and global levels. It is thereby suggested that promising AYUSH formulations and Indian medicinal plants must be investigated on a priority basis to solve the current crisis.

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Section: Piper Nigrum L (Black Pepper)mentioning

confidence: 72%

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

et al. 2021

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“…Natural resources have attracted considerable interest by many scientists on the natural extracts identification due to their potential applications in treating human health problems and enhancing food security (Li et al, 2014(Li et al, , 2015. Traditional spices and food flavoring agents, such as star anise and black pepper, date back several thousand years (Liu Q. et al, 2020;Pei et al, 2020;Wang et al, 2021). They played important roles in clinical therapy and the food industry due to their beneficial medical use (Moghaddasi et al, 2018;Kamoun et al, 2019;Li H. et al, 2019), strong pharmacological activity (Abukawsar et al, 2018;Yu et al, 2020), antioxidant potential (Liu et al, 2008), and low cost (Destro et al, 2019;Orrillo et al, 2019;Ding et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Multistage Extraction of Star Anise and Black Pepper Derivatives for Antibacterial, Antioxidant, and Anticancer Activity

et al. 2021

Front. Chem.

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Recently, natural resources have attracted considerable interest for their applications in food security and human health problems. Traditional natural spices, such as star anise and black pepper, played important roles in the pharmaceutical and food industries due to their strong pharmacological activity, antioxidant potential and rare complications. In order to achieve biomasses from the natural product with multiple bioactivities, we developed the multistage extraction method to extract and separate various bioactive compounds from these natural plants. Our work demonstrated that various bioactive-rich extractives were achieved using steam distilled- or oxidative-extraction methods with high extraction yields and purity. Furthermore, the extractives in each step can be used not only as bioactive compounds, but also as a resource to further prepare different derivatives during the next extractive step, providing biomass-saving to a great extent. The extractives obtained with high yields and purities (>82%) were identified by 1H NMR, 13C NMR, FTIR, UV-vis, fluorescence spectroscopy, and high-performance liquid chromatography (HPLC). Moreover, these biomasses display potent antibacterial activities against some types of microorganisms such as S.aureus, S.pyogenes, E.coli, and S.typhi with a lowest MIC of 400 μg/ml for the development of antibacterial agents, significant antioxidant activity as the natural antioxidant for enhancing food shelf-life, and excellent anticancer activity that induces significant cancer cell apoptosis. This work showed the different multistage extracts from natural products, which enable them to be applied in the fields of the pharmaceutical industry and the food industry.

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“…The bioactive compounds present in African potato are terpenoids, saponins, tannin, reducing sugars, phytoglycosides, and sterols Increased lysozyme, protease, and bactericidal activity Fish Zhang et al, 2020;Beltrán et al, 2020;Espirito Espirito Santo et al, 2018;Mabrok and Wahdan, 2018;Shourbela et al, 2021;Rashidian et al, 2021 Increased specific Ig Broiler chicken Galal et al, 2016;Franciosini et al, 2016 -Moreno et al, 2017;Wang-sheng et al, 2017;Ren and Liang, 2018;Pei et al, 2020;Mao et al, 2017;Viswanadha et al, 2020 Inhibited macrophage inflammation in pancreatic islets Mouse Yuan et al, 2021 Treated allergic inflammatory through major T helper cell groups Mouse Bui et al, 2017;Bui et al, 2019 Chili powders (Capsicum species)…”

Section: Bioactive Compoundsmentioning

confidence: 99%

“…Various alkaloids within black pepper have been shown to ameliorate LPS-induced inflammation in mouse models. Levels of LPSinduced pro-inflammatory cytokines IL-1β, TNF-α, and IL-6 were reduced by guineensine (Reynoso-Moreno et al, 2017), piperine (Wang-sheng et al, 2017;Ren and Liang, 2018), and three alkaloids of unknown identity (Pei et al, 2020). Additionally, piperine and the three unknown alkaloids were shown to inhibited LPSstimulated pro-inflammatory Prostaglandin E 2 release (Wangsheng et al, 2017;Pei et al, 2020).…”

Section: Anti-inflammatory Propertiesmentioning

confidence: 99%

Spices and herbs as immune enhancers and anti-inflammatory agents: a review

Garnier¹,

Shahidi²

2021

Journal of Food Bioactives

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Spices and herbs have been used in traditional medicine for centuries, with research starting to accumulate on their beneficial properties. Of these properties, the immune-enhancing and anti-inflammatory capabilities of many spices and herbs have led to promising results. The current review article aims to explore the current research of several spices and herbs as immune-enhancers and anti-inflammatory agents. The spices and herbs examined are African potato (Hypoxis hemerocallidea), allspice (Pimenta dioica), basil (Ocimum basilicum), black pepper (Piper nigrum), chili powders (Capsicum species), clove (Syzygium aromaticum), Devil’s claw (Harpagophytem procumbens), fenugreek (Trigonella foenum-graecum), ginger (Zingiber officinale), lavender (Lavandula angustifolia), oregano (Origanum vulgare), rooibos (Aspalathus linearis), rosemary/sage (Salvia rosmarinus/officinalis), saffron (Crocus sativus), South African geranium (Pelargonium sidoides), and turmeric (Curcuma longa). All the spices and herbs exhibited immune-enhancing or immunomodulatory and anti-inflammatory capabilities through various processes. Rooibos and oregano had the most contradictory results, with some studies finding pro-inflammatory properties, especially at high doses regarding oregano. Turmeric had the most extensive research with positive results.

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Alkaloids from Black Pepper (Piper nigrum L.) Exhibit Anti-Inflammatory Activity in Murine Macrophages by Inhibiting Activation of NF-κB Pathway

Cited by 60 publications

References 53 publications

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

Multistage Extraction of Star Anise and Black Pepper Derivatives for Antibacterial, Antioxidant, and Anticancer Activity

Spices and herbs as immune enhancers and anti-inflammatory agents: a review

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