Alkaloids from Glaucium corniculatum (L.) of Egyptian origin

Comparison of alkaloid profile from Glaucium corniculatum (Papaveraceae) of Algerian and Bulgarian origin

“…More than 20 isoquinoline alkaloids have been reported for Glaucium corniculatum (Kiryakov and Panov, 1970;Novak, 1972;Phillipson et al, 1981;Shafiee et al, 1985;Al-Wakeel et al, 1995;Kintsurashvili and Vachnadze, 2000). The major alkaloid is allocryptopine which is accompanied by protopine and corydine.…”

“…The biosynthesis of the type of isoquinoline alkaloids depends on various factors such as genetics of plants, stage of development, geographical origin and environment. For instance, in regions with a continental climate, like the Czech Republic, G. corniculatum produces a large number of benzophenathridine alkaloids such as sanguinarine and chelerythrine, while in regions with tropical climate such as Iran, Iraq and Egypt these alkaloids are missing (Novak, 1972;Phillipson and Gray, 1981;Shafiee et al, 1985;Al-Wakeel et al, 1995). Aporphine alkaloids such as glaucine, dicentrine, dehydroglaucine, dehydrodicentrine and bulbocapnine are characteristics of G. corniculatum ssp.…”

Naturally occurring plant isoquinoline N-oxide alkaloids: Their pharmacological and SAR activities

“…Isocorydine was identified from many other plants (Ribar 2003;El-Sawi and Motawe 2003;Goeren et al 2003;Mat 2000), and shown antiviral activity against HSV-1 (Nawawi et al 1999). Alkaloid (27) was found in plant Glaucium corniculatum from Egypt, and other glaucentrine N-oxide (28) (known as (+)-corydine N-oxide) (Al-Wakeel et al 1995). Eight annual Turkish Papaver species from sections Argemonidium (P. argemone), Carinatae (P. macrostomum), Mecones (P. gracile) and Rhoeadium, (P. commutatum subsp.…”

The anti-AChE and anti-proliferative Activities of Glaucium acutidentatum and Glaucium corniculatum Alkaloid Extracts

“…One of these species is Glaucium corniculatum, known to be traditionally used to treat memory impairment (Ahmed et al, 2013) and have a very high potency of inhibiting AChE (Mehta et al, 2012;Orhan and Sener, 2004;Das et al, 2002;Perry et al, 2001;Perry et al, 2000). Moreover, G. corniculatum stands out with its richness of alkaloid content (Shafiee et al, 1985;Doncheva et al, 2002;Novak et al, 1972;Phillipson et al, 1981;Al-Wakeel et al, 1995). The other is G. acutidentatum.…”