Alkaloids from <i>Piper longum</i> Exhibit Anti-inflammatory Activity and Synergistic Effects with Chemotherapeutic Agents against Cervical Cancer Cells

Qian, Wei; Xu, Jie; Zhu, Chengjing; Liu, Xingxing; Tu, Yijun; Lei, Jiachuan; Yu, Jianqing

doi:10.1021/acs.jafc.3c01667

Cited by 15 publications

(1 citation statement)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rhizoma A. has extensive pharmacological activities, which include antitumor, anti-inflammation, anticonvulsant, and antibacterial activities . Also, Cortex A., Piper L., and Angelica D. have outstanding anti-inflammatory activity and are often used as therapeutic candidates for inhibiting inflammation-mediated diseases. − …”

Section: Introductionmentioning

confidence: 99%

Novel Hydrogel Adjuvant of Chinese Medicine External Preparations for Accelerated Healing of Deep Soft Tissue Injuries

Wang,

Xia,

et al. 2024

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Traditional Chinese medicine external prescriptions have displayed excellent clinical effects for treating deep soft tissue injuries. However, the effects cannot be fully utilized due to the limitations of their dosage forms and usage methods. It is still a challenge to develop a satisfactory adjuvant of traditional Chinese medicine external prescriptions. Herein, a hydrogel adjuvant was prepared based on gallic acid coupled ε-poly-L-lysine and partially oxidized hyaluronic acid. The resulting adjuvant shows great physicochemical properties, low hemolysis rate (still much less than 5% at 5 mg/mL), excellent antibacterial ability (about 95% at 2 mg/mL), strong antioxidant ability (1.687 ± 0.085 mmol FeSO 4 /(g hydrogel) at 1 mg/mL), as well as outstanding biocompatibility. A clinically used Chinese medicine external preparation was selected as an example to investigate the effectiveness of the adjuvant in treating deep soft tissue injuries. The results show that the prescription can be evenly dispersed in the adjuvant. Moreover, the introduction of the prescription has not significantly changed these advanced properties of the adjuvant. Importantly, the hydrogel adjuvant significantly improves the effectiveness of the prescription in treating deep soft tissue injuries. This work offers an alternative approach to the development of a new-type adjuvant of Chinese medicine external preparations and also provides a new strategy for the combination of traditional Chinese medicine and hydrogel to treat clinical diseases.

show abstract

Section: Introductionmentioning

confidence: 99%

Novel Hydrogel Adjuvant of Chinese Medicine External Preparations for Accelerated Healing of Deep Soft Tissue Injuries

Wang,

Xia,

et al. 2024

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

Alkaloids from Piper longum L and their Anti‐inflammatory Properties

Phuong Tran,

Nhiem,

Pham‐The

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Piper longum L.(PL) is considered one of the most important species traditionally used for treating various ailments and has indicated the presence of alkaloids, flavonoids, and steroids. In this study, we isolated the chemical compounds of PLleaves,andmeasuredNO, IL‐6, iNOS, as well as COX‐2 protein levels. In addition, molecular docking analysis were used to further understand anti‐inflammation effect of the compounds. We identified one new alkaloid named piperlongumine A (1) with ten known compounds (2‐11). The new compound (1) and two other alkaloids 2E)‐3‐(4‐hydroxy‐3‐methoxyphenyl)‐1‐(pyrrol‐1‐yl)propanone (7) and piperchabamide A (8) significantlyreduced NO production in LPS‐stimulated RAW 264.7 cells with the IC50 values of 0.97 ± 0.05 mM, 0.91 ± 0.07mM, 1.63 ± 0.14 mM, respectively. Moreover, at concentration of 2 mM, compound 1 inhibited approximately 98 ± 0.64 % of IL‐6 secretion, and decreased iNOS and COX‐2 protein level by about 96 and 19 folds compared to LPS treatment alone, respectively. Furthermore, compounds 1, 7, and 8 were predicted to bind and inhibit IL‐6, TNF‐a, and iNOS, with compound 1 showing the highest binding energy of ‐7.09 kcal/mol. This study provides new insights for potential anti‐inflammatory drug design and warrants further investigation.

show abstract

The draft genome of Piper longum L.

Mathew,

Valsalan

2024

Crop Science

View full text Add to dashboard Cite

Genome of Piper longum (long pepper, Piperaceae), an important medicinal plant, is being reported. The sequencing was carried out on Illumina Novaseq‐6000 platform at 150x coverage, and de novo scaffold‐level assembly has resulted in a 447.7 Mb genome (89,204 scaffolds with an N50 value of 10.7 kb). Even though long pepper is valued for its pungent alkaloids, especially piperine, mechanism of piperine biosynthesis is yet to be revealed. Functional annotation of the genes has given a better understanding of the genomic features and genes involved in piperine biosynthesis. Phylogenetic relationship of long pepper with other members of Piperaceae family and the expression of Piperine synthase and Piperamide synthase genes in the developing leaves and spikes were also analyzed. The results indicated that this medicinal plant may have genes similar to black pepper involved in the biosynthesis of piperine. Raw reads and the assembly are made publicly available.

show abstract

Alkaloids from Piper longum Exhibit Anti-inflammatory Activity and Synergistic Effects with Chemotherapeutic Agents against Cervical Cancer Cells

Cited by 15 publications

References 44 publications

Novel Hydrogel Adjuvant of Chinese Medicine External Preparations for Accelerated Healing of Deep Soft Tissue Injuries

Novel Hydrogel Adjuvant of Chinese Medicine External Preparations for Accelerated Healing of Deep Soft Tissue Injuries

Alkaloids from Piper longum L and their Anti‐inflammatory Properties

The draft genome of Piper longum L.

Contact Info

Product

Resources

About