Alkaloids from Isopyrum thalictroides L.

Istatkova, Ralitsa; Philipov, Stefan

doi:10.1016/s0031-9422(00)00068-6

Cited by 15 publications

(10 citation statements)

References 5 publications

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“…Approximately 36 compounds have been reported in Isopyrum, of which 6 are flavonols and 30 are benzylisoquinoline alkaloids, including kaempferol, kaempferol-3,7-O-diglucoside, and magnoflorine. [33][34][35][36] Comparing the chemical constituents of the genus Isopyrum previously reported with the present analysis of Dichocarpum, flavonols with a kaempferol skeleton and benzylisoquinoline alkaloids appeared in both genera, and the genus Isopyrum possessed more diverse alkaloid structural types. There are currently no studies of triterpenes saponins in the genus Isopyrum.…”

Section: Comparison Of Chemical Constituents Within and Between Genera Of Dichocarpummentioning

confidence: 74%

Metabolite Profiling Based on UPLC‐Q‐TOF‐MS/MS and the Biological Evaluation of Medicinal Plants of Chinese Dichocarpum (Ranunculaceae)

Shen

et al. 2021

Chemistry & Biodiversity

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The genus Dichocarpum is endemic to East Asia, and many species have been used to treat various diseases. However, phytochemical researches of this genus have been limited to date. In the present study, a metabolomic approach based on UPLC‐Q‐TOF‐MS/MS was used to explore the phytochemical profiles of 10 Chinese Dichocarpum species, and cannabinoid receptor (CB1/CB2) agonistic activities evaluation of these plants was performed. A total of 128 features were putatively annotated, belonging to alkaloids, flavonoids, triterpenes saponins, phenolic acids, and others. Semi‐quantitative statistics demonstrated that alkaloids and flavonoids were widely distributed, with the former the most abundant, whereas triterpenes saponins were mainly distributed in D. fargesii and D. wuchuanense. The phylogenetic results obtained from DNA sequencing assigned the 10 species to three groups. Further results of in silico annotation revealed three chemical families and helped determine the characteristic features of the three groups. In addition, the plant extracts of nine species from this genus showed agonistic activity on CB2 receptors. This comprehensive analysis revealed the chemotype distribution and pharmacophylogenetic relationship, to provide clues for the prospective resource utilization of the medicinal plants from the genus Dichocarpum.

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Section: Comparison Of Chemical Constituents Within and Between Genera Of Dichocarpummentioning

confidence: 74%

Metabolite Profiling Based on UPLC‐Q‐TOF‐MS/MS and the Biological Evaluation of Medicinal Plants of Chinese Dichocarpum (Ranunculaceae)

Shen

et al. 2021

Chemistry & Biodiversity

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“…Isocorydine (6a S )-1,2,10-trimethoxy-6-methyl-5,6,6a,7-tetrahydro-4 H -dibenzo[de,g]quinoline-11-ol, Figure 12) is an aporphine benzylisoquinolinic alkaloid. This alkaloid has been isolated from many plant parts and species such as: twigs of Annona squamosa (Annonaceae) [102], roots and rhizomes of Isopyrum thalictroides (Ranunculaceae) [113], roots of Dactylicapnos scandens (Papaveraceae) [114], Corydalis saxicola (Papaveraceae) [115], Doryphora sassafras (Monimiaceae) [116], leaves of Aquilaria sinensis (Thymelaeaceae) [117], stems and leaves of Stephania cephalantha (Menispermaceae) [118] and Aconitum brachypodum (Ranunculaceae) [119].…”

Section: Resultsmentioning

confidence: 99%

Activity of Alkaloids on Peptic Ulcer: What’s New?

Nascimento¹,

Sales²,

Formiga³

et al. 2015

Molecules

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Peptic ulcer is a common disease characterized by lesions that affect the mucosa of the esophagus, stomach and/or duodenum, and may extend into the muscular layer of the mucosa. Natural products have played an important role in the process of development and discovery of new drugs, due to their wide structural diversity and present, mostly specific and selective biological activities. Among natural products the alkaloids, biologically active secondary metabolites, that can be found in plants, animals or microorganisms stand out. The alkaloids are compounds consisting of a basic nitrogen atom that may or may not be part of a heterocyclic ring. This review will describe 15 alkaloids with antiulcer activity in animal models and in vitro studies.

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“…Annona purpurea 23 reticuline Hernandia nymphaefolia 40 reticuline Isopyrum thalictroides 41 reticuline Miliusa velutina 42 reticuline Monodora junodii 43 norgorchacoine* 64 Papaver triniifolium 44 crykonisine…”

Section: Benzylisoquinolinesmentioning

confidence: 99%

“…Coupling of this with the tributylstannylnaphthalene 62 by the Stille process afforded N-benzyl-O,Obis(methoxymethyl)dioncophylline B 63, which was hydrolysed and debenzylated to dioncophylline B 48. 39 4 Benzylisoquinolines 1-Benzylisoquinoline alkaloids have been isolated from the following plant species, that marked with an asterisk being a new alkaloid: Annona purpurea 23 reticuline Hernandia nymphaefolia 40 reticuline Isopyrum thalictroides 41 reticuline Miliusa velutina 42 reticuline Monodora junodii 43 norgorchacoine* 64 Papaver triniifolium 44 crykonisine…”

Section: Naphthylisoquinolinesmentioning

confidence: 99%

“…Annona glabra 2 dehydrocorydalmine and kikemanine Asteropyrum cavaleriei 89 berberine, berberubine and palmatine Isopyrum thalictroides 41 columbamine and palmatine Lindera glauca 90 canadine (tetrahydroberberine) Papaver triniifolium 44 cheilanthifoline, isocorypalmine, sinactine and N-methylsinactine Polyalthia longifolia 91 8-oxopolyalthiaine* 97 Rollinia leptopetala 92,93 discretamine and tetrahydrojatrorrhizine Thalictrum acutifolium 94 acutiaporberine* 98 Thalictrum orientale 61 berberine Zanthoxylum taediosum 95 isocorypalmine, kikemanine, scoulerine, tetrahydropalmatine and cis-N-methyltetrahydropalmatine…”

Section: Berberines and Tetrahydroberberinesmentioning

confidence: 99%

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β-Phenylethylamines and the isoquinoline alkaloids

Bentley

2002

Nat. Prod. Rep.

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This review covers beta-phenylethylamines and isoquinoline alkaloids that are derived from them, including further products of oxidation, condensation with formaldehyde and rearrangement, some of which do not contain an isoquinoline system, together with naphthylisoquinoline alkaloids, which have a different biogenetic origin. The occurrence of the alkaloids, with the structures of new bases, together with their reactions, syntheses and biological activities are reported. The literature from July 2000 to June 2001 is reviewed, with 495 references cited.

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Alkaloids from Isopyrum thalictroides L.

Cited by 15 publications

References 5 publications

Metabolite Profiling Based on UPLC‐Q‐TOF‐MS/MS and the Biological Evaluation of Medicinal Plants of Chinese Dichocarpum (Ranunculaceae)

Metabolite Profiling Based on UPLC‐Q‐TOF‐MS/MS and the Biological Evaluation of Medicinal Plants of Chinese Dichocarpum (Ranunculaceae)

Activity of Alkaloids on Peptic Ulcer: What’s New?

β-Phenylethylamines and the isoquinoline alkaloids

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