Alkaloids from Marine Ascidians

Menna, Marialuisa; Fattorusso, Ernesto; Imperatore, Concetta

doi:10.3390/molecules16108694

Cited by 53 publications

(41 citation statements)

References 220 publications

(267 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An indole based alkaloid, Eudistomin K isolated from the Caribbean ascidian Eudistoma olivaceum was found to be potent against human lung cancer (A-549) cell lines. It is reported to inhibit the P-388 tumor cell line with IC 50 of 0.01 µg/mL ( Figure 13) [115].…”

Section: Miscellaneous Indole Derivatives In Anti-lung Cancer Treatmentmentioning

confidence: 99%

Role of Indole Scaffolds as Pharmacophores in the Development of Anti-Lung Cancer Agents

Dhuguru

Skouta

2020

Molecules

View full text Add to dashboard Cite

Lung cancer is the leading cause of death in men and women worldwide, affecting millions of people. Between the two types of lung cancers, non-small cell lung cancer (NSCLC) is more common than small cell lung cancer (SCLC). Besides surgery and radiotherapy, chemotherapy is the most important method of treatment for lung cancer. Indole scaffold is considered one of the most privileged scaffolds in heterocyclic chemistry. Indole may serve as an effective probe for the development of new drug candidates against challenging diseases, including lung cancer. In this review, we will focus on discussing the existing indole based pharmacophores in the clinical and pre-clinical stages of development against lung cancer, along with the synthesis of some of the selected anti-lung cancer drugs. Moreover, the basic mechanism of action underlying indole based anti-lung cancer treatment, such as protein kinase inhibition, histone deacetylase inhibition, DNA topoisomerase inhibition, and tubulin inhibition will also be discussed.

show abstract

Section: Miscellaneous Indole Derivatives In Anti-lung Cancer Treatmentmentioning

confidence: 99%

Role of Indole Scaffolds as Pharmacophores in the Development of Anti-Lung Cancer Agents

Dhuguru

Skouta

2020

Molecules

View full text Add to dashboard Cite

show abstract

“…While the majority of metabolites isolated from ascidians are nitrogen-containing compounds (alkaloids or peptide related compounds), ascidians belonging to the genus Aplidium are known as a rich source of meroterpenes [5,6,7]. The first biologically active tunicate metabolite was indeed geranylhydroquinone ( 2 ), isolated from an Aplidium sp.…”

Section: Meroterpenes From Ascidiansmentioning

confidence: 99%

Meroterpenes from Marine Invertebrates: Structures, Occurrence, and Ecological Implications

et al. 2013

Self Cite

View full text Add to dashboard Cite

Meroterpenes are widely distributed among marine organisms; they are particularly abundant within brown algae, but other important sources include microorganisms and invertebrates. In the present review the structures and bioactivities of meroterpenes from marine invertebrates, mainly sponges and tunicates, are summarized. More than 300 molecules, often complex and with unique skeletons originating from intra- and inter-molecular cyclizations, and/or rearrangements, are illustrated. The reported syntheses are mentioned. The issue of a potential microbial link to their biosynthesis is also shortly outlined.

show abstract

“…Together with cephalostatins, isolated from the marine worm Cephalodiscus gilchristi, they make up a unique family of 45 trisdecacyclic bis-steroidal pyrazines that display extremely potent cytotoxicity against human tumors with unique cell selectivity and apoptotic response [29][30][31]. The outstanding antineoplastic potency, together with the new and challenging molecular architecture, made these marine invertebrate alkaloids promising anticancer leads.…”

Section: Bis-steroidal Pyrazines: Ritterazines and Cephalostatins Pomentioning

confidence: 99%

Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development

et al. 2014

Self Cite

View full text Add to dashboard Cite

Abstract:The present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Recent discoveries concerning the current state of the potential and/or development of some of them as new drugs, as well as the current knowledge regarding their modes of action, are also summarized. A special emphasis is given to the role of marine invertebrate alkaloids as an important source of leads for anticancer drug discovery.

show abstract

Alkaloids from Marine Ascidians

Cited by 53 publications

References 220 publications

Role of Indole Scaffolds as Pharmacophores in the Development of Anti-Lung Cancer Agents

Role of Indole Scaffolds as Pharmacophores in the Development of Anti-Lung Cancer Agents

Meroterpenes from Marine Invertebrates: Structures, Occurrence, and Ecological Implications

Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development

Contact Info

Product

Resources

About