Alkaloids from species. XII. Glutarimide peptides from L.

Kutney, James P.; Klein, Frederick K.; Eigendorf, Guenter K.; McNeill, D.; Stuart, K. L.

doi:10.1016/s0040-4039(01)97603-8

Cited by 6 publications

(2 citation statements)

References 2 publications

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“…Since the spectral data and the optical rotation of one of our hydrolysis products matched the data reported for (S)-2-amino-1-phenylethanol [10][11][12], the stereocenter C-14 of 1 was assigned as (S). The configurations of C-6 and C-9 were assigned both as (S) by comparing the rest of our hydrolysis products with authentic samples of L-(þ) glutamic acid and (S)-(þ)-2-methylbutanoic acid [13][14][15][16]. Compound 2 was obtained as a green oil from the dichloromethane extract.…”

Section: Resultsmentioning

confidence: 99%

Three new Glutarimide Alkaloids fromCroton Cuneatus

Suárez

Blanco

Monachè

et al. 2004

Natural Product Research

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Analysis of the dichloromethane extract of the aerial parts of Croton cuneatus led to the isolation of the new glutarimide alkaloids: julocrotol (1), isojulocrotol (2), and julocrotone (3) along with the known compounds julocrotonine (4), lichexanthone (5) and selin-11-en-4alpha-ol (6). The structures of the new compounds were established by spectral methods. The in vitro cytotoxic activity of Compounds 1-6 was evaluated against six human tumor cells lines.

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Section: Resultsmentioning

confidence: 99%

Three new Glutarimide Alkaloids fromCroton Cuneatus

Suárez

Blanco

Monachè

et al. 2004

Natural Product Research

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“…9 Cordiarimides A (3) and B ( 4 Glutarimide alkaloids isolated from Croton cuneatus were previously reported to exhibit cytotoxic activity. 11 Glutarimide alkaloids have been found in the genus Croton, 10,11,13,16,17 except for julocrotine from Julocroton monteVidensis. 12 This is the first report on the presence of glutarimide alkaloids in the genus Cordia.…”

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Glutarimide Alkaloids and a Terpenoid Benzoquinone from Cordia globifera

et al. 2010

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Three new compounds, a meroterpene (2) having a cyclopropane moiety named globiferane and glutarimide alkaloids named cordiarimides A (3) and B (4), were isolated from the roots of Cordia globifera. Compounds 2-4 exhibited weak cytotoxic activity. Cordiarimide B (4) exhibited radical scavenging activity, as it inhibited superoxide anion radical formation in the xanthine/xanthine oxidase (XXO) assay, and also suppressed superoxide anion generation in differentiated HL-60 human promyelocytic leukemia cells when induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). This is the first report on the presence of glutarimide alkaloids in the genus Cordia.

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