Alkaloids from the leaves of Monodora crispata Engl. and Diels and M. brevipes Benth. (Annonaceae)

Kablan, Landry; Dade, Joël M.E.; Timothée, Okpekon Aboua; Roblot, François; Djakouré, Léon Atoutou; Champy, Pierre

doi:10.1016/j.bse.2012.09.024

Cited by 6 publications

(13 citation statements)

References 27 publications

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“…296.1281 mDa =0.1). The NMR spectra of 2 (Table 2) exhibited characteristic signals at δH 2.56 ppm (3H, s) and δC 42.7ppm, corresponding to an aporphine alkaloid, suchlike an N-methyl (Kablan et al, 2013;Dade et al, 2017). The combined analysis of its 13 C NMR and HSQC spectra revealed the presence of eighteen carbons: five methine, four methylene and eight quaternary carbon atoms.…”

Section: Resultsmentioning

confidence: 99%

“…1) were established according to their spectral data (NMR, IR and MS). Their stereochemistry was proposed on the basis of optical rotation measurement, in comparison with the literature (Hocquemiller et al, 1981;Spiff et al, 1984;Chang et al, 1995;Slvaki al., 1996;Kablan et al, 2013, Dade et al, 2017. [(1H, dd (8.4, 1.6), H-6)] and 8.18 (1H, H-4).…”

Section: Isolationmentioning

confidence: 99%

“…In addition to their medicinal potential, several species of Monodora are used to build housing. Monodora genus is a reach source of bioactive compounds like alkaloids (Leboeuf et al, 1982;Kablan et al, 2013, Dade et al, 2017, sesquiterpenes, monoterpenes, diterpenes (Etse et al, 1989), indole (Etse et al, 1989) and essential oils (Fournier et al, 1999;Owokotomo et al, 2012;Dje et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…is one of four Monodora species found in Côte d'Ivoire (Kablan et al, 2013). It is a small tree distributed in the southern coastal humid zones of Côte d'Ivoire.…”

Section: Introductionmentioning

confidence: 99%

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A new natural indole and three aporphine alkaloids from Monodora bevipes Benth. (Annonaceae)

et al. 2017

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Four compounds were isolated from the leaves of Monodora brevipes Benth. (Annonaceae). Among them, one new natural indole named 5-formylindole (1) and three known aporphine alkaloids: (+)-roemeroline (2); (+)-corydine (3) and (+)-menispermine (4). They were isolated for the first time from this species. The structures of these compounds were established according to their spectral data (NMR, SM, IR and UV).Eric et al., International Current Pharmaceutical Journal, June 2017, 6(7): 40-43http://www.icpjonline.com/documents/Vol6Issue7/01.pdf

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Section: Resultsmentioning

confidence: 99%

Section: Isolationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…is one of four Monodora species found in Côte d'Ivoire (Kablan et al, 2013). It is a small tree distributed in the southern coastal humid zones of Côte d'Ivoire.…”

Section: Introductionmentioning

confidence: 99%

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A new natural indole and three aporphine alkaloids from Monodora bevipes Benth. (Annonaceae)

et al. 2017

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“…Eleven aporphines alkaloids ( Figure 1 (11) isolated from the dried powdered leaves of M. crispata and brevipes [11,12] were used in this study. …”

Section: Isolated Compoundsmentioning

confidence: 99%

Antileishmanial and Trypanocidal Activities of Extracts and Aporphine Alkaloids Isolated from Monodora Genus (Annonaceae)

Dade¹,

Kablan²,

Attioua³

et al. 2017

J Pharmacogn Nat Prod

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Leishmaniasis and trypanosomiasis are protozoan diseases caused respectively by the kinetoplastid protozoan Leishmania parasites transmitted by the female phlebotomine sandflies and Trypanosoma parasites transmitted by the tsetse fly. In the search for agents from tropical medicinal plants to treat these two neglected tropical diseases, serially extracted petroleum ether, dichloromethane and methanol extracts of the leaves of Monodora crispata and Monodora brevipes, and eleven aporphines alkaloids isolated from the dried powdered leaves of the two plants were evaluated against Leishmania donovani promastigotes and Trypanosoma brucei brucei trypomastigotes. The extracts of both plants and the isolated compounds displayed varied levels of antiprotozoal activities. The oxoaporphine compounds, (+)-anolobine (7) and (+)-listeferine (8), exerted the most significant activity against L. donovani (IC 50 : 14.59 µM) and T. brucei brucei (LC 100 : 50.02 µM) respectively. This is the first report on the antiprotozoal activity of the isolated compounds. The results offer potential for further studies of the oxoaporphines for enhanced antiprotozoal activity.

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Chemistry and biology of ent-morphinan alkaloids

Keita,

Duval,

Porée

2023

The Alkaloids: Chemistry and Biology

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Alkaloids from the leaves of Monodora crispata Engl. and Diels and M. brevipes Benth. (Annonaceae)

Cited by 6 publications

References 27 publications

A new natural indole and three aporphine alkaloids from Monodora bevipes Benth. (Annonaceae)

A new natural indole and three aporphine alkaloids from Monodora bevipes Benth. (Annonaceae)

Antileishmanial and Trypanocidal Activities of Extracts and Aporphine Alkaloids Isolated from Monodora Genus (Annonaceae)

Chemistry and biology of ent-morphinan alkaloids

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