Alkaloids from the Tribe Bocconieae (Papaveraceae): A Chemical and Biological Review

Abstract

Abstract:The Bocconieae tribe, consisting of only the genera Macleaya and Bocconia, possesses significant economic and medicinal value and plays an important role in health management for people in developing countries. During the past decades, research on metabolites and relative pharmacology, including the isolation and identification of a variety of molecules, has shed light on the tribe. Among those molecules, isoquinoline alkaloids, and their antimicrobial, antifungal, and anti-inflammatory activities are especially noteworthy. This paper presents a comprehensive compilation of current research progress, with emphasis on the alkaloids and their distribution, phytochemical and pharmacological investigation, toxicity and side effects, related chemotaxonomy and future use prospects, and hopefully provides a valuable reference as an effort to promote further exploration and application of this tribe.

Phytochemical and biological research of Chelidonieae pharmaceutical resources

“…6)dihydrochelerythrin I A a Roots Lei et al (2014) 2 Maclekarpine D I A a Roots Yu et al (2014) 3 ( 5 0 R)-3 0 -Methyl-2 0 (5 0 H)furanone-(5 0 ! 6)dihydrosanguinarine ¼ maclekarpine E I A a Roots Lei et al (2014) and Yu et al (2014) 8 11-Acetonyldihydrochelerythrine I A b Barks Lei et al (2014) 9 6-Acetonyl-dihydrosanguinarine I A a Whole plants Lei et al (2014) and Yu et al (2014) b Aerial parts c Whole plants d 6)-(6S)-dihydrosanguinarine ¼ maclekarpine B I A a Roots Lei et al (2014) and Yu et al (2014) 5 ( 5 0 R)-3 0 -Methyl-2 0 (5 0 H)furanone-(5 0 !…”

“…Fruits, stems l Leaves 10 6-Acetonyl-dihyrochelerythrine I A b Barks, aerial parts Lei et al (2014) and Yu et al (2014) …”

“…Benzophenanthridines (BPAs) are predominant in Bocconia and Macleaya, followed by protoberberines, protopines, and other types (Yu et al, 2014). The BPA type of alkaloids, derived from protoberberines via N-C6 bond cleavage and the formation of C6-C13 bonds, is one of the characteristic and chemotaxonomic components in the family Papaveraceae.…”

Synthesis of N -methyl-5,6-dihydrobenzo[ c ]phenanthridine and its sp 3 C(6)–H bond functionalization via oxidative cross-dehydrogenative coupling reactions

“…[1][2][3][4] Notwithstanding that several synthetic strategies have been reported for natural and nonnatural compounds having the benzophenanthridine scaffold, [5][6][7][8][9] the direct C H functionalization of this heterocycle remains unexplored as an alternative strategy to generate structural diverse compounds in the quest for new drugs. 10,11 As part of our continued interest in the development or application of synthetic methods to the functionalization of heterocyclic scaffolds that occur in natural products, 12 we recently became interested in the direct sp 3 C H functionalization of DHB (1).…”

Endophytic fungi residing in medicinal plants have the ability to produce the same or similar pharmacologically active secondary metabolites as their hosts

“…Most of the SA currently used in herbal supplements and medicines is extracted from M. cordata. Recently, SA has gained increasing attention as a potential agent in the treatment of cancer (Yu et al, 2014).…”