Alkaloids from three ethnomedicinal Haemanthus species: H. albiflos, H. deformis and H. pauculifolius (Amaryllidaceae)

Crouch, Neil R.; Pohl, Tracy; Mulholland, Dulcie A.; Ndlovu, E.; Staden, J. Van

doi:10.1016/s0254-6299(15)30148-4

Cited by 14 publications

(10 citation statements)

References 15 publications

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“…In turn, H. pauculifolius was shown to contain homolycorine (4), paucamine salt (55), homolycorine salt (88), montanine salt (94) and manthidine salt (95) [39]. The protonated quaternary ammonium salts were released as free bases upon treatment with NaOH [39]. As previously noted [15], and in line with the findings of this study, montanine compounds appear to be quite ubiquitous to the genus Haemanthus.…”

supporting

confidence: 88%

“…Lastly, work by Kamatou et al on the fruits of Gethyllis afra and G. ciliaris indicated the presence of 72 known volatile compounds, mostly esters, as determined by GC-MS after solid phase micro-extraction [43]. The following year Van Rijn et al investigated Nerine bowdenii as a potential source of AChE inhibitory compounds [44], in the process identifying five -crinane alkaloids, ambelline (38), buphanisine (44), undulatine (57), 11-O-acetylambelline (39) and filifoline (42). Of these, only undulatine was notably active against the AChE enzyme, with an IC 50 of 37 M.…”

Section: Alkaloids Of the Of South African Amaryllidaceaementioning

confidence: 99%

“…Furthermore, none of the compounds exhibited antioxidant activity as determined by the DPPH radical scavenging assay [38]. [39]. To this extent, H. albiflos gave the known alkaloids homolycorine (4), albomaculine (87) and O-methyllycorenium salt (91), while coccinine (93), montanine (6 and manthidine salt (95) were identified in H. deformis [39].…”

mentioning

confidence: 99%

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Alkaloids of the South African Amaryllidaceae: A Review

Bastida

Codina

et al. 2013

Natural Product Communications

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The plant family Amaryllidaceae is known for its horticultural and ornamental appeal as well as its medicinal value. In relation to these characteristics, trade in Amaryllid flower varieties (especially daffodils) is a multi-million dollar revenue generator for the floriculture industry. Of greater significance are the medicinal attributes of the family, which has already spawned the Alzheimer's prescription drug galanthamine, a potent and selective inhibitor of the enzyme acetylcholinesterase, of significance in the progression of neurodegeneration associated with motor neuron diseases, with annual global sales of around $150 million. Furthermore, it is anticipated that an anticancer drug target related to the Amaryllidaceae alkaloid pancratistatin, presently under advanced clinical evaluation, will enter commercial circulation within the next decade. Members of the Amaryllidaceae are distributed through both tropical and subtropical regions of the globe, but are of prominence within three distinct geographical locations, including Andean South America, the Mediterranean basin, and southern Africa. The southern African zone is known to harbor at least a third of the worldwide complement of around 1000 species, many of which are widely utilized in the traditional medicinal practices of the indigenous people of the region. Given its therapeutic and economic value, its natural abundance in the southern African region, coupled to its widespread usage in ethnic medicine, the family Amaryllidaceae provides a diverse and accessible platform for phytochemical based drug discovery. A consolidation of its traditional usage as well as its chemical and pharmacological profiles will thus guide efforts aimed at maximizing this potential. In undertaking this survey of the Amaryllidaceae of southern African, we aimed to achieve these goals.

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confidence: 88%

Section: Alkaloids Of the Of South African Amaryllidaceaementioning

confidence: 99%

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Alkaloids of the South African Amaryllidaceae: A Review

Bastida

Codina

et al. 2013

Natural Product Communications

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“…In vitro antimycobacterial activity of fifty-eight extracts from ten plants; G. foliosa (bark), H. Husson et al, 1994and 1997, Crouch et al, 2005 Anacardiaceae Protorhus longifolia (Bernh.) Engl…”

Section: Antimycobacterial Activitymentioning

confidence: 99%

“…Both the bark (acetone, ethanol and hot water) and leaf (acetone, ethanol and water) extracts of P. echinatus showed moderate antimycobacterial activity against at least five Mycobacterium strains. Homolycorine, albomaculine, albimanthine, and O-methyl-lycorenium salt reportedly isolated from H. albiflos(Baudoin et al, 1994;Crouch et al, 2005) could be responsible for moderate antimycobacterial activity shown by the leaf acetone extracts of this plant (against M. smegmatis and M. fortuitum) and bulbs (against M. bovis BCG and M. gordonae).…”

mentioning

confidence: 99%

Scientific rationale for traditional use of plants to treat tuberculosis in the eastern region of the OR Tambo district, South Africa

Madikizela

McGaw

2018

Journal of Ethnopharmacology

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The Inhibition of RNA Viruses by Amaryllidaceae Alkaloids: Opportunities for the Development of Broad‐Spectrum Anti‐Coronavirus Drugs

Tan

Banwell

et al. 2022

Chemistry An Asian Journal

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The global COVID‐19 pandemic has claimed the lives of millions and disrupted nearly every aspect of human society. Currently, vaccines remain the only widely available medical means to address the cause of the pandemic, the SARS‐CoV‐2 virus. Unfortunately, current scientific consensus deems the emergence of vaccine‐resistant SARS‐CoV‐2 variants highly likely. In this context, the design and development of broad‐spectrum, small‐molecule based antiviral drugs has been described as a potentially effective, alternative medical strategy to address circulating and re‐emerging CoVs. Small molecules are well‐suited to target the least‐rapidly evolving structures within CoVs such as highly conserved RNA replication enzymes, and this renders them less vulnerable to evolved drug resistance. Examination of the vast literature describing the inhibition of RNA viruses by Amaryllidaceae alkaloids suggests that future, broad‐spectrum anti‐CoV drugs may be derived from this family of natural products.

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Alkaloids from three ethnomedicinal Haemanthus species: H. albiflos, H. deformis and H. pauculifolius (Amaryllidaceae)

Cited by 14 publications

References 15 publications

Alkaloids of the South African Amaryllidaceae: A Review

Alkaloids of the South African Amaryllidaceae: A Review

Scientific rationale for traditional use of plants to treat tuberculosis in the eastern region of the OR Tambo district, South Africa

The Inhibition of RNA Viruses by Amaryllidaceae Alkaloids: Opportunities for the Development of Broad‐Spectrum Anti‐Coronavirus Drugs

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