Alkaloids from Traditional Chinese Medicine against hepatocellular carcinoma

Liu, Caiyan; Yang, Shenshen; Wang, Kailong; Bao, Xiaomei; Liu, Yiman; Zhou, Shiyue; Liu, Hongwei; Qiu, Yuling; Wang, Tao; Yu, Haiyang

doi:10.1016/j.biopha.2019.109543

Cited by 131 publications

(92 citation statements)

References 136 publications

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“…According to the molecular model, a binding site of AChE can interact with positively charged nitrogen to inhibit AChE activity [70,71]. According to the structure, alkaloids can be divided into piperidine alkaloids, isoquinoline alkaloids, indole alkaloids, terpenoids, steroids and other alkaloids, mainly distributed within Buxaceae, Amaryllidaceae and Lycopodiaceae [72,73]. We compared and summarized the roles of different categories of alkaloids in extraction methods and neurodegenerative diseases, as shown in Table 3.…”

Section: Comparison Of Different Alkaloidsmentioning

confidence: 99%

Traditional Chinese medicine for anti-Alzheimer’s disease: berberine and evodiamine from Evodia rutaecarpa

et al. 2020

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Alzheimer's disease (AD) is one of the most common diseases in elderly people with a high incidence of dementia at approximately 60-80%. The pathogenesis of AD was quite complicated and currently there is no unified conclusion in the academic community, so no efficiently clinical treatment is available. In recent years, with the development of traditional Chinese medicine (TCM), researchers have proposed the idea of relying on TCM to prevent and treat AD based on the characteristic of multiple targets of TCM. This study reviewed the pathological hypothesis of AD and the potential biomarkers found in the current researches. And the potential targets of berberine and evodiamine from Evodia rutaecarpa in AD were summarized and further analyzed. A compound-targets-pathway network was carried out to clarify the mechanism of action of berberine and evodiamine for AD. Furthermore, the limitations of current researches on the TCM and AD were discussed. It is hoped that this review will provide some references for development of TCM in the prevention and treatment of AD.

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Section: Comparison Of Different Alkaloidsmentioning

confidence: 99%

Traditional Chinese medicine for anti-Alzheimer’s disease: berberine and evodiamine from Evodia rutaecarpa

et al. 2020

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“…Previous studies have demonstrated that alkaloids have a well‐recognized role in preventing and treating HCC. Instead of directly killing cancer cells, alkaloids are prospective in the promotion of cancer cell apoptosis, autophagy, necrosis, the disruption of cell cycle, the inhibition of cell growth, proliferation, differentiation, migration, and invasion, as well as the regulation of immune systems 18 . These findings suggest a promising basis for potential new chemical entities with easily accessed terrestrial originated plants rich in alkaloids.…”

Section: Introductionmentioning

confidence: 99%

HTBPI, an active phenanthroindolizidine alkaloid, inhibits liver tumorigenesis by targeting Akt

Liu

Chen

et al. 2020

FASEB j.

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Akt, a crucial protein involved in a variety of signaling pathways in cancer, acts as an important regulator of survival in hepatocellular carcinoma (HCC), and provides curative option for the related drugs development. We have found an active phenanthroindolizidine alkaloid, (13aR,14R)‐9,11,12,13,13a,14‐hexahydro‐3,6,7‐trimethoxydibenzo[f,h]pyrrolo[1,2‐b]isoquinolin‐14‐ol (HTBPI), is a promising Akt inhibitor effective in the suppression of HCC cells proliferation through stimulating apoptotic and autophagic capability in vivo and in vitro. Treatment of HTBPI combined with a classical autophagy‐lysosomal inhibitor (bafilomycin A1), could enhance stimulation effects of apoptosis on HCC cell lines. In addition, we confirmed HTBPI targeting Akt, occupied the kinase binding domain (Thr 308) of Akt to inactivate its function by CETSA and DARTS assay. In contrast, ectopic Akt‐induced overexpression significantly abrogated inhibitory effects of HTBPI on cell viability and proliferation. Furthermore, high p‐Akt (Thr 308) expression is collated with liver tumor formation and poor survival in HCC patients. In conclusions, HTBPI impeded HCC progress through regulation of apoptosis and autophagy machinery via interaction with p‐Akt (Thr 308). This may provide potential molecular candidate by targeting Akt for the therapy of HCC patients.

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“…Hepatocellular carcinoma generally has no clinical symptoms in the early stage, and 2/3 of cases are found in the middle and advanced stage, when only about 20% of patients are suitable for surgical resection . Vascular invasion or extrahepatic tumor spread lead to no curative treatment options available.…”

Section: Introductionmentioning

confidence: 99%

The diagnostic value of PIVKA‐II, AFP, AFP‐L3, CEA, and their combinations in primary and metastatic hepatocellular carcinoma

Zhou

et al. 2019

Clinical Laboratory Analysis

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Background: Early diagnosis decreases the mortality of hepatocellular carcinoma (HCC). We aimed to investigate the usefulness of PIVKA-II, AFP, AFP-L3, CEA, and their combinations in the diagnosis of primary and metastatic HCC. Methods: One hundred and twenty patients with primary HCC (PHC), 115 with metastatic HCC (MHC), 89 with chronic liver disease (CLD), and 116 healthy volunteers were included. The diagnostic values of each marker and their combinations for HCC diagnosis were represented by ROC curve analyses.Results: PIVKA-II, AFP, and AFP-L3 levels in PHC group were higher than that in normal control, CLD, and MHC groups. CEA levels in MHC group were higher than that in the other three groups. When the four markers were analyzed individually, PIVKA-II showed the highest positive rate in PHC group (76.7%) and CEA showed the highest positive rate in MHC group (69.6%). PIVKA-II showed the largest area under ROC curve (AUC = 0.835) to discriminate PHC group from CLD group. Combined PIVKA-II with AFP-L3 increased the AUC to 0.910. CEA showed the highest AUC (0.849) to discriminate MHC group from CLD group. Combined CEA with PIVKA-II increased the AUC to 0.866. AFP-L3 alone showed the highest AUC (0.890) to discriminate MHC group from PHC group. Combined PIVKA-II with AFP-L3, and CEA increased the AUC to 0.957. Conclusion: PIVKA-II, AFP-L3, AFP, and CEA are effective biomarkers for the diagnosis of PHC and MHC. Their combinations could improve the diagnostic performance compared with each marker used alone in detecting PHC and MHC. K E Y W O R D S AFP, AFP-L3, CEA, hepatocellular carcinoma, PIVKA-II

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Alkaloids from Traditional Chinese Medicine against hepatocellular carcinoma

Cited by 131 publications

References 136 publications

Traditional Chinese medicine for anti-Alzheimer’s disease: berberine and evodiamine from Evodia rutaecarpa

Traditional Chinese medicine for anti-Alzheimer’s disease: berberine and evodiamine from Evodia rutaecarpa

HTBPI, an active phenanthroindolizidine alkaloid, inhibits liver tumorigenesis by targeting Akt

The diagnostic value of PIVKA‐II, AFP, AFP‐L3, CEA, and their combinations in primary and metastatic hepatocellular carcinoma

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