Alkaloids in<i>Thalictrum</i>Species from Mongolia

Velcheva, Margarita; Dutschewska, H.; Danghaaghiin, Selenghe; Samdanghiin, Zhavzhan; Yansanghiin, Zhamyansan

doi:10.1055/s-2006-961057

Cited by 6 publications

(4 citation statements)

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“…Hernandia nymphaeifolia [168] Hernandia sonora [164] [168] Preocoteine [2] -OH -OCH 3 -H -CH 3 -H -OCH 3 -OCH 3 -H Ranuncudaceae: Thalictrum Preocoteine N-oxid [2] (N→O) -OH -OCH 3 -H -CH 3 -H -OCH 3 -OCH 3 -H Ranuncudaceae: Thalictrum O-Demethylpuepareine [2] -OCH 3 -OCH 3 -OH -CH 3 -H -OCH 3 -OCH 3 -H Annonaceae: Annona Norpureine [2] -OCH 3 -OCH 3 -OCH 3 -H -H -OCH 3 -OCH 3 -H Annonaceae: Annona Thalicsimidine -OCH 3 -OCH 3 -OCH 3 -CH 3 -H -OCH 3 -OCH 3 -H Annona purpurea [125] Thalictrum flavum L [169] Oconovine -OCH 3 -OCH 3 -OCH 3 -CH 3 -H -H -OCH 3 -OH Thalictrum fauriei [170] Ocokryptine [2] -…”

Section: Ovigerine -O-ch 2 -O--h -H -H -H -O-ch 2 -O-mentioning

confidence: 99%

Aporphine Alkaloids: A Kind of Alkaloids’ Extract Source, Chemical Constitution and Pharmacological Actions in Different Botany

Chen¹,

Gao²,

Liu³

et al. 2013

Asian J. Chem.

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As a kind of common compositions in plants, there are many researches about alkaloids, which was firstly found from Nelumbo nucifera. Now more and more aporphine alkaloids appear during the experiments, which belong to isoquinoline type. There are number of pesticide effects about them, which have been revealed in recent years. So comprehensive information about the locality, formation and pesticide effects have been studied and presented in this research in different botany about aporphine alkaloids.

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Section: Ovigerine -O-ch 2 -O--h -H -H -H -O-ch 2 -O-mentioning

confidence: 99%

Aporphine Alkaloids: A Kind of Alkaloids’ Extract Source, Chemical Constitution and Pharmacological Actions in Different Botany

Chen¹,

Gao²,

Liu³

et al. 2013

Asian J. Chem.

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“…Hernandezine is a biologically active constituent bisbenzylisoquinoline alkaloid of Thalictrum flavum (Ranunculaceae), which has not previously been reported as a selective modulator of ABCB1 to our knowledge, but has been identified as having many biological activities. − Hernandezine has been shown capable of protecting hair cells from aminoglycoside-induced damage, inhibiting protein kinase C signaling events in human peripheral blood T cells and neuronal nicotinic acetylcholine receptors (nAChRs), and blocking non-voltage-operated Ca 2+ entry activated by intracellular Ca 2+ store depletion induced by thapsigargin in rat glioma C6 cells and in human leukemic HL-60 cells . Moreover, hernandezine was identified recently as the most effective isoquinoline alkaloid to induce autophagic cell death via direct activation of AMP-activated protein kinase (AMPK) .…”

mentioning

confidence: 99%

Hernandezine, a Bisbenzylisoquinoline Alkaloid with Selective Inhibitory Activity against Multidrug-Resistance-Linked ATP-Binding Cassette Drug Transporter ABCB1

Hsiao¹,

Yang³

et al. 2016

J. Nat. Prod.

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The overexpression of ATP-binding cassette (ABC) drug transporter ABCB1 (P-glycoprotein, MDR1) is the most studied mechanism of multidrug resistance (MDR), which remains a major obstacle in clinical cancer chemotherapy. Consequently, resensitizing MDR cancer cells by inhibiting the efflux function of ABCB1 has been considered as a potential strategy to overcome ABCB1-mediated MDR in cancer patients. However, the task of developing a suitable modulator of ABCB1 has been hindered mostly by the lack of selectivity and high intrinsic toxicity of candidate compounds. Considering the wide range of diversity and relatively nontoxic nature of natural products, developing a potential modulator of ABCB1 from natural sources is particularly valuable. Through screening of a large collection of purified bioactive natural products, hernandezine was identified as a potent and selective reversing agent for ABCB1-mediated MDR in cancer cells. Experimental data demonstrated that the bisbenzylisoquinoline alkaloid hernandezine is selective for ABCB1, effectively inhibits the transport function of ABCB1, and enhances drug-induced apoptosis in cancer cells. More importantly, hernandezine significantly resensitizes ABCB1-overexpressing cancer cells to multiple chemotherapeutic drugs at nontoxic, nanomolar concentrations. Collectively, these findings reveal that hernandezine has great potential to be further developed into a novel reversal agent for combination therapy in MDR cancer patients.

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“…majus 41 96 O -Methylthalmethine (C 37 H 38 O 6 N 2 : 606.2730) Thalictrum minus (Ranunculaceae) 66 97 Thalicberine (C 37 H 40 O 6 N 2 : 608.2886) Thalictrum minus (Ranunculaceae), T. minus var. majus 41 98 Thalmethine (C 36 H 36 O 6 N 2 : 592.2573) Thalictrum minus (Ranunculaceae) 66 99 Thalfoetidine (C 38 H 42 O 7 N 2 : 638.2992) Thalictrum fargesii , , T. flavum 63 100 Thalidasine (C 39 H 44 O 7 N 2 : 652.3149) Thalictrum fargesii (Ranunculaceae), , T. flavum , T. foetidum 49 116 Nortiliacorinine A (C 35 H 34 O 5 N 2 : 562.2468) Tiliacora racemosa (Menispermaceae) 119 Tiliacorinine (C 36 H 36 O 5 N 2 : 576.2624) Tiliacora racemosa (Menispermaceae) 68 120 Tiliamosine (C 36 H 36 O 6 N 2 : 592.2573) Tiliacora racemosa (Menispermaceae) 8 121 Cycleanine (C 38 H 42 O 6 N 2 : 662.3042) Stephania cepharantha (Menispermaceae) 28,31,33 122 Isochondodendrine (C 36 H 38 O 6 N 2 : 594.2730) Cyclea sutchuenensis (Menispermaceae), Stephania epigaea (Menispermaceae) 32 125 (−)-Norcycleanine (C 37 H 40 O 6 N 2 : 608.2886) Stephania cepharantha (Menispermaceae) 28 133 (−)-Curine (C 36 H 38 O 6 N 2 : 594.2730) Cyclea barbata (Menispermaceae), Stephania epigaea (Menispermaceae) 32 152 Cocsoline (C 34 H 32 O 5 N 2 : 548.2311) Cocculus pendulus (Menispermaceae) 55 153 Cocsuline (C 35 H 34 O 5 N 2 : 562.2468) Cocculus pendulus (Menispermaceae), , Pachygone dasycarpa (Menispermaceae) 9 155 12‘- O -Demethyltrilobine (C 34 H 32 O 5 N 2 : 548.2311) Cocculus pendulus (Menispermaceae) 55 …”

unclassified

Bisbenzylisoquinoline Alkaloids

Schiff

1997

J. Nat. Prod.

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Alkaloids inThalictrumSpecies from Mongolia

Cited by 6 publications

References 0 publications

Aporphine Alkaloids: A Kind of Alkaloids’ Extract Source, Chemical Constitution and Pharmacological Actions in Different Botany

Aporphine Alkaloids: A Kind of Alkaloids’ Extract Source, Chemical Constitution and Pharmacological Actions in Different Botany

Hernandezine, a Bisbenzylisoquinoline Alkaloid with Selective Inhibitory Activity against Multidrug-Resistance-Linked ATP-Binding Cassette Drug Transporter ABCB1

Bisbenzylisoquinoline Alkaloids

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