Alkaloids in Meadow Saffron,<i>Colchicum autumnale</i>L.

Poutaraud, Anne; Girardin, Philippe

doi:10.1300/j044v09n01_08

Cited by 13 publications

(15 citation statements)

References 10 publications

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“…However, conditions in the field vary and the choice of the harvest date remained difficult. Moreover, alkaloid content decreases during seed maturation (Godet 1987;Poutaraud and Girardin 2002). We observed differences in maturity within the studied population.…”

Section: Discussionmentioning

confidence: 67%

“…We hence sought to allow only these two parameters to vary. As determined during a previous study (Godet 1987;Poutaraud and Girardin 2002), we tried to choose the date of harvest on the basis of the appearance of the first dehiscent capsule, that is to say when the outside of the capsule became brownish and the seeds began to turn brown. However, conditions in the field vary and the choice of the harvest date remained difficult.…”

Section: Discussionmentioning

confidence: 99%

“…Once the dry capsules had been beaten to extract the seeds, the clean seeds were weighed and stored in a hermetically closed container at 4°C from 1 to 5 mo, then finely ground (< 0.1 mm). Extraction and high-pressure liquid chromatography assays were made according to techniques presented in Poutaraud and Girardin (2002). The equipment used before 1999 is presented in that paper.…”

Section: Treatment and Analysis Of Samplesmentioning

confidence: 99%

“…Little is known about the factors determining alkaloid content and yield in meadow saffron. Only the influence of the harvest stage has been studied, showing that seed alkaloid content declines as the seeds mature (Godet 1987;Poutaraud and Girardin 2002). The impact of cultivated production on seed quality and the influence of climatic conditions have not yet been studied.…”

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confidence: 99%

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Seed yield and components of alkaloid of meadow saffron (Colchicum autumnale) in natural grassland and under cultivation

Girardin¹

2003

Can. J. Plant Sci.

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Poutaraud, A. and Girardin, P. 2003. Seed yield and components of alkaloid of meadow saffron (Colchicum autumnale) in natural grassland and under cultivation. Can. J. Plant Sci. 83: 23-29. Alkaloids extracted from meadow saffron seeds are used in numerous medicines. To test the influence of cultivation and climatic conditions on the production and the quality of meadow saffron seeds, we studied seed alkaloid yield on a natural site (grassland) and in a cultivated crop over several years. Seeds contained in capsules harvested before their dehiscence were dried and ground. The alkaloids of the extracts (colchicoside, demethylcolchicine and colchicine) were analyzed by high-pressure liquid chromatography. Seed alkaloid content was not influenced by year, inter-plant competition, or number of capsules per plant. Seed dry matter yield per plant, however, practically tripled in the cultivated crop due to an increase in the number of capsules per plant compared to the grassland. In the cultivated crop, 47% of fruiting plants produced two new plants (corms) every year. Four years after planting, this vegetative multiplication resulted in intraspecific competition, inducing a decline in seed yield per plant linked to a decrease in the weight of seeds per capsule. We were able to show that cultivated production of meadow saffron greatly increased dry matter and alkaloid yield per plant and per hectare, but that it could lead to the need to thin after several years. Les alcaloïdes extraits des graines de colchiques entrent dans la composition de nombreux médicaments. Afin de tester l'influence de la mise en culture et des conditions climatiques sur la production de graines de colchique, nous avons étudié les composantes du rendement en alcaloïdes en prairie et en culture durant plusieurs années. Les graines contenues dans les capsules récoltées avant leur déhiscence ont été séchées, broyées. Les alcaloïdes extraits ont été analysés en chromatographie en phase liquide. Les teneurs en alcaloïdes n'ont été influencées ni par l'année de culture, ni par la concurrence entre plantes (inter ou intraspécifique), ni par le nombre de capsules par plante. Par contre, le rendement en graines sèches par plante a pratiquement triplé à cause de la levée de la concurrence interspécifique (prairie), essentiellement du fait d'une augmentation du nombre de capsules par plante. En culture, 47 % des plantes fructifères se sont dédoublées chaque année. A partir de la 4 ème année de culture, cette multiplication a entraîné une concurrence intraspécifique provoquant une baisse de rendement en graines par plante liée essentiellement à une diminution du poids de graines par capsule. Ainsi, nous avons pu montrer que la mise en culture des colchiques augmentait de façon importante le rendement en matière sèche par plante et par hectare mais pouvait nécessiter un démariage après plusieurs années.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Treatment and Analysis Of Samplesmentioning

confidence: 99%

mentioning

confidence: 99%

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Seed yield and components of alkaloid of meadow saffron (Colchicum autumnale) in natural grassland and under cultivation

Girardin¹

2003

Can. J. Plant Sci.

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“…The economic valuation of hay from these highly valuable grasslands would be a way of ensuring their preservation at an ecological level. However, CFP grasslands can include significant proportions of Colchicum autumnale (Plantureux and Amiaud, 2010), commonly known as meadow saffron (MeS), which is highly toxic for numerous animal species (Scherrmann et al, 1989) due to the presence of the alkaloid colchicine in the plant (Poutareau and Girardin, 2002). Moreover, feed preferences of rabbits concerning rich hay is unknown and their willingness to ingest these plants or not needs to be studied.…”

Section: Introductionmentioning

confidence: 99%

Intake of different hays with presence of Colchicum autumnale by rabbits

et al. 2017

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The ingestion of 3 hay types by growing rabbits and the consequences on animal performance were studied in a first part. Two kinds of hay from high nature value grasslands [CFP (Colchico-Festucetum pratensis) and SBR (Senecioni-Brometum racemosi)] differentiated by their botanical composition were compared to a classical agricultural hay (control). The 3 hays, offered ad libitum, were ingested at 30.6, 34.8 and 36.1 g/kg body weight (BW) respectively for SBR, CFP and the control, where the consumption of SBR hay was significantly lower. (P<0.01). The type of hay distributed did not affect the consumption of commercial feed or growth (44 g/kg BW and 36 g/d, respectively). The effect of meadow saffron concentration (Colchicum autumnale) in CFP hay was tested at 3 doses (absence, 2.75 and 15% of the distributed hay mass) with respect to their effect on ingestion and animal health. Again, no effect of the presence of meadow saffron (MeS) in the hay on these parameters was observed, even at the highest dose. However, during this second part, rabbits preferred to consume meadow saffron instead of the rest of the distributed hay (hardly any MeS was refused by rabbits at the representative dose, whereas 12% of the rest of the hay was refused, and 3.4 and 20% respectively at the maximal dose). The intake of the toxic alkaloid colchicine corresponded to 30 to 44% of the median lethal doses (LD 50 ) at the representative and maximal doses respectively. The real exposure of the rabbits was probably lower, as the absorption of ingested colchicine is reported to be around 50% of the LD 50 values which are established after an intravenous injection. Nevertheless, the absence of any effect should be interpreted with caution. The colchicine content of MeS varied greatly depending on the time of harvest and the parts of the plant taken into consideration. A late harvest (mid-June or later) would ensure (very) low concentrations of colchicine in the aerial parts of MeS. The presence of cloves on this plant should be completely avoided, due to the very high concentration of colchicine in the seeds. Moreover, long term exposure of the animals to this toxic plant may increase the risk of adverse effects. The study shows that hay distribution can aid digestion without altering the animal's performance. Moreover, the valorisation of hay from high nature value grasslands would not only add real value to the commercialisation of rabbit meat by commercial breeders, but also to pet owners on the condition that hay quality would be guaranteed.

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Therapeutic Properties of Herbal Constituents Subjected for Clinical Trials

Vatsa,

Aggarwal

2023

Bioprospecting of Tropical Medicinal Plants

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Alkaloids in Meadow Saffron,Colchicum autumnaleL.

Cited by 13 publications

References 10 publications

Seed yield and components of alkaloid of meadow saffron (Colchicum autumnale) in natural grassland and under cultivation

Seed yield and components of alkaloid of meadow saffron (Colchicum autumnale) in natural grassland and under cultivation

Intake of different hays with presence of Colchicum autumnale by rabbits

Therapeutic Properties of Herbal Constituents Subjected for Clinical Trials

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