Alkaloids of the stem bark of Alstonia lanceolifera

Ravao, Thérèse; Richard, Bernard; Sévenet, Thierry; Massiot, Georges; Men‐Olivier, L. Le

doi:10.1016/0031-9422(82)83081-1

Cited by 9 publications

(1 citation statement)

References 9 publications

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“…(H. zeylanica) is a Thai plant (Apocynaceae) that can be found in the Eastern and the Southern parts of the country (Hooker, 1980(Hooker, -1982Ridley, 1923;Whitmore, 1973). The chemical constituents from the leaves and stem bark of H. zeylanica have been investigated and identified (Ravao et al, 1982;Arambewela & Khuong-Huu, 1981;Takayama et al, 1994Takayama et al, , 1995Subhadhirasakul et al, 1994aSubhadhirasakul et al, ,b, 1995.…”

Section: Introductionmentioning

confidence: 99%

Analgesic and Antipyretic Activities of n-Butanol Alkaloids Extracted from the Stem Bark Hunteria Zeylanica and its Major Constituent, Strictosidinic Acid, in Mice

Reanmongkol

Subhadhirasakul

Kongsang

et al. 2000

Pharmaceutical Biology (Formerly International Journal of Pharm

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The pharmacological activities of the n-butanol alkaloids extracted from the stem bark of Hunteria zeylanica (Retz) Gardn. ex Thw. (H. zeylanica) and its major constituent, strictosidinic acid, on nociceptive response using writhing and hot plate tests, the antipyretic activity in yeast-induced fever, pentobarbital-induced sleep, and locomotor activity were examined in mice. Oral administration of H. zeylanica extract at 200 mg/kg significantly decreased the number of contortions and stretchings induced by acetic acid but not heat-induced pain. Strictosidinic acid (5-20 mg/kg, p.o.) also produced a similar effect but less pronounced than the extract. The antipyretic effect of strictosidinic acid (5-20 mg/kg, p.o.) was stronger than that of the extract (100-200 mg/kg, p.o.). The H. zeylanica extract dose-dependently (50-200 mg/kg, p.o.) prolonged the duration of pentobarbital-induced sleep but had no significant effect on locomotor activity. No effect of strictosidinic acid was noted on both pentobarbital-induced sleep and locomotor activity. These results suggest that the H. zeylanica extract possesses peripheral analgesic and mild antipyretic effects and its major constituent, strictosidinic acid, exerts a similar analgesic effect with marked antipyretic activity.

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Section: Introductionmentioning

confidence: 99%

Analgesic and Antipyretic Activities of n-Butanol Alkaloids Extracted from the Stem Bark Hunteria Zeylanica and its Major Constituent, Strictosidinic Acid, in Mice

Reanmongkol

Subhadhirasakul

Kongsang

et al. 2000

Pharmaceutical Biology (Formerly International Journal of Pharm

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Preakuammicine: A Long‐Awaited Missing Link in the Biosynthesis of Monoterpene Indole Alkaloids

et al. 2016

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(16S)-Preakuammicine has been considered a key intermediate in the biosynthesis of monoterpene indole alkaloids since the 1970s. Indeed, preakuammicine plays a crucial role in the biosynthesis of type II and type III monoterpene indole alkaloids and strychnine. In this paper, we disclose the unprecedented biomimetic transformation of akuammiline into (16R)-acetylpreakuammicine, which ultimately gives mechanistic in-

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Applications of1H and13C NMR spectroscopy in structural investigations of Vinca indole alkaloids

Yagudaev¹

1986

Chem Nat Compd

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Alkaloids of the stem bark of Alstonia lanceolifera

Cited by 9 publications

References 9 publications

Analgesic and Antipyretic Activities of n-Butanol Alkaloids Extracted from the Stem Bark Hunteria Zeylanica and its Major Constituent, Strictosidinic Acid, in Mice

Analgesic and Antipyretic Activities of n-Butanol Alkaloids Extracted from the Stem Bark Hunteria Zeylanica and its Major Constituent, Strictosidinic Acid, in Mice

Preakuammicine: A Long‐Awaited Missing Link in the Biosynthesis of Monoterpene Indole Alkaloids

Applications of1H and13C NMR spectroscopy in structural investigations of Vinca indole alkaloids

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