Alkaloids, plants, structure, properties

Abstract

1294 alkaloids arranged in alphabetical order t with details of their producing plants and of the structure, composition, and melting points of the alkaloids and their derivatives, specific rotations, solubilities, spectral characteristics (UV, IR, PMR, 13C NMR, etc.), information on pharmacology, and references to original papers and to unpublished investigations. UV spectra were taken in ethanol (kma x, nm; log c); IR spectra, as a rule, for molded tablets with KBr (cm-1), and 1H and 13C NMR spectra in deuterochloroform (6 scale, ppm, values of J in Hz), except where otherwise mentioned.Abbreviations of the literature sources encountered most frequently are given in Chapter 1 of this review.Conventional symbols and abbreviations used in the review:{ } --the melting points of characteristic derivatives are given within braces;

In vitro anti-proliferative activity of Argemone gracilenta and identification of some active components

“…Argemonine. Mp 122.3-123.4°C (melting point of reference 147-148°C [ 19 ]), 1 H NMR (CDCl 3 , 400 MHz), δ ppm; 2.52 (d, J = 6.0 Hz, Hα-5 and Hα-11), 2.45 (s, N-CH 3 ), 4.04 (dd, J = 6.61 Hz, H-6 and H-12) 3.58 (s, 3-OCH 3 and 9-OCH 3 ), 3.66 (2-OCH 3 and 8-OCH 3 ), 3.33 (d, J = 5.2 Hz, Hβ-5 and Hβ-11), 6.31 (s, H-1 and H-7), 6.47 (H-4 and H-10). 13 C NMR (CDCl 3 , 100 MHz), δ ppm; 33.3 (C-5 and C-11), 39.7 (N-CH 3 ), 56.3 (C-6 and C-12), 55.6 (3-OCH 3 and 9-OCH 3 ), 55.8 (2-OCH 3 and 8-OCH 3 ), 109.7 (C-4 and C-10), 111.3 (C-1 and C-7), 122.5 (C-4a and C-10a), 127.4 (C-1a and C-7a), 147.9 (C-3 and C-9), 148.4 (C21 and C-8).…”

“…Berberine. Mp 144.3-146.1°C (melting point of reference 146°C [ 19 ]) 1 H NMR (CD 3 OD, 400 MHz), δ ppm; 3.26 (t, J = 5.6 Hz, H-5), 4.12 (s, 9-OCH 3 ), 4.35 (s, 10-OCH 3 ), 4.95 (t, J = 5.6 Hz, H-6), 6.13 (s, 3-OCH 2 O), 6.89 (s, H-4), 7.45 (s, H-1), 7.95 (d, J = 7.98, H-12), 8.00 (d, J = 7.98, H-11), 8.61 (s, H-13), 9.78 (s, H-8). 13 C NMR (CD 3 OD, 100 MHz), δ ppm; 28.2 (C-5), 57.1 (C-6), 57.6 (9-OCH 3 ), 62.5 (10-OCH 3 ), 103.6 (2,3-OCH 2 O), 106.5 (C-1), 109.3 (C-4), 121.5 (C-13), 121.9 (C-4a), 123.3 (C-12a), 124.5 (C-12), 128 (C-11), 131.9 (C-14a), 135.1 (C-8a), 139.6 (C-14), 145.7 (C-9), 146.4 (C-8), 149.9 (C-3), 152 (C-2 and C-10).…”

Screening of 14 alkaloids isolated from Haplophyllum A. Juss. for their cytotoxic properties

“…The alkaloids were identified with authentic samples (Shakirov et al, 1996), according to their physico-chemical constants and spectral data (UV, IR, mass, and 1 H NMR spectra) or by direct comparison of the samples (TLC, mp of a mixed probe, IR spectra).…”

Cytotoxic Effects of Haplamine and its Major Metabolites on Human Cancer Cell Lines

“…and Kir. at the Institute of Plant Substances (Tashkent, Uzbekistan) according to the procedure cited previously [7] and identified by comparison with an authentic sample [8]. Trans/cis-3,4dihydroxyhaplamines were synthesized from haplamine as described previously [5].…”