Alkenylation of C(sp³)−H Bonds by Zincation/Copper‐Catalyzed Cross‐Coupling with Iodonium Salts

Abstract

α‐Vinylation of phosphonates, phosphine oxides, sulfones, sulfonamides, and sulfoxides has been achieved by selective C−H zincation and copper‐catalyzed C(sp3)−C(sp2) cross‐coupling reaction using vinylphenyliodonium salts. The vinylation transformation proceeds in high efficiency and stereospecificity under mild reaction conditions. This zincative cross‐coupling reaction represents a general alkenylation strategy, which is also applicable for α‐alkenylation of esters, amides, and nitriles in the synthesis of β,γ‐unsaturated carbonyl compounds.