Alkenylresorcinols and cytotoxic activity of the constituents isolated from Labisia pumila

Al‐Mekhlafi, Nabil Ali; Shaari, Khozirah; Abas, Faridah; Kneer, Ralf; Jeyaraj, Ethel Jeyaseela; Stanslas, Johnson; Yamamoto, Naoshi; Honda, Toshio; Lajis, Nordin Hj

doi:10.1016/j.phytochem.2012.04.008

Cited by 32 publications

(26 citation statements)

References 34 publications

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“…L. pumila traditionally used to induce and facilitate childbirth, as health supplement, as treatment for rheumatism, intestine infection, prostate cancer, dysentery, dysmenorrheal, flatulence and gonorrhea [1][2][3]. Previous scientific studies revealed that the extract of L. pumila enclosed many medically worthy bioactive compounds such as phenolics, flavonoids, vitamins and proteins that poses numerous biological effects (antibacterial, antioxidant, anticancer, antiobesity, cytotoxic) [4][5][6][7][8]. Many authors had recognized gallic acid as the core compound of L. pumila [5,[9][10].…”

Section: Introductionmentioning

confidence: 99%

The effect of particle size and solvent type on the gallic acid yield obtained from Labisia pumila by ultrasonic extraction

et al. 2017

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Abstract. This paper presents the effect of particle size and solvent type on the gallic acid (GA) extraction yield obtained from Labisia pumila. The GA extraction from a grinded dried plant material (66.66 μm to 1055.18 μm) was performed using the sonicator probe. The GA quantification and identification was performed using a liquid chromatography with photodiode array detector. Exact match between the spectra obtained from the plant extract and external standard was found indicating a presence of GA. In addition, matching of residence time between the standard and plant extract are also observed. It was found that particle size significantly affects the yield of GA and the highest yield (0.150 mg GA/g DW) was obtained using the particle size around 125 μm. Solvent type does also plays an important role in GA extraction. The result shows that extraction using water as solvent yielded about 29% higher GA content (0.126 mg GA/g DW) than that of 10% ethanol (0.098 mg GA/g DW). The findings in this work may serve as a useful guide to select the particle size and solvent used to maximise GA extraction from L. pumila.

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Section: Introductionmentioning

confidence: 99%

The effect of particle size and solvent type on the gallic acid yield obtained from Labisia pumila by ultrasonic extraction

et al. 2017

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“…The studies of Sánchez et al [97], Chuang and Wu [98], and Al-Mekhlafi et al [101] confirmed the findings of Kubo et al [102] on cytotoxicity of ARs against human breast cancer cell lines. Kubo et al found that ARs and their methyl derivatives also exhibited significant cytotoxicity against human cervical cancer cell lines HeLa.…”

Section: Cytotoxic Activities Of Alkylresorcinolsmentioning

confidence: 58%

“…The ability of ARs to inhibit the growth of prostate, colon, and breast cancer cells has been confirmed by AlMeklafi et al [101]. Twelve isolated ARs from an important medicinal herb in Malaysia were tested and two ARs (structurally very closely related) exhibited the most cytotoxic activity against PC-3, HCT-116, and MCF-7 human cancer cell lines, and were more active than doxorubicin at the IC 50 level.…”

Section: Cytotoxic Activities Of Alkylresorcinolsmentioning

confidence: 79%

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Dietary alkylresorcinols and cancer prevention: a systematic review

Kruk

Aboul‐Enein

Bernstein

et al. 2017

Eur Food Res Technol

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nervous system, adenocarcinoma, hepatocarcinoma, cervix squamous carcinoma, and ovarian cancer cell lines, at micromolar alkylresorcinols concentration. Evidence from prospective studies confirmed significant inverse associations between whole grains intake and distal colon cancer risk. Model studies suggest a high cytotoxicity of alkylresorcinols toward cancer cells. These findings maintain that alkylresorcinols as components of whole grains are likely to find application in cancer prevention; however, the need for intervention studies to confirm their preventive action is warranted. Abstract The potential role of alkylresorcinol compound from whole grains for prevention and inhibition of human cancer cell lines has been reported in observational and in vitro studies. The objective of this study was to present an updated review on the association between alkylresorcinols and cancer risk and aspects of their bioactivity with implications for carcinogenesis. Relevant studies were identified by searching PubMed, Scopus, ProQuest, EBSCOhost, SpringerLink, ArticleFirst, Taylor & Francis, Wiley Online, and ScienceDirect electronic databases using these search terms and key words: alkylresorcinols, cancer, carcinoma, risk. Furthermore, references from retrieved articles were also reviewed. Four observational and 10 in vitro studies were included in the analysis of natural or synthetic alkylresorcinols for anticancer activities. Two prospective studies reported a 52-66% risk reduction of distal colon cancer at nanomolar alkylresorcinols concentration in plasma; the remaining studies found no reduction of endometrial cancer risk and an approximate 40% increase in prostate cancer risk. In vitro studies presented inhibition of human colon, breast, lung, central Keywords

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“…3. Inhibiting proliferation via the activation of caspase-3 and caspase-9, up-regulation of the ratio of bax/bcl-2 protein expression in Ardisia brevicaulis [61] Artocarpus obtusus [50,62] Ardisia brecaulis [63], Carica papaya [64] Catharanthus roseus [118][119], Costus speciosus [121][122], Cucuma zedoaria [65], Dysoxylum cauliforum [66], Goniosthalamus macrophyllus [137][138], Gynura procumbens [139], Lawsonia inermis [56,[146][147], Leea indica [148][149], Nepthelium lappaceum [56,156] Pandanus amarylfolius [41], Phyla nodiflora [67], Physalis minima [52,78], Rhodiola rosea [68], Vernonia amygdalina [65] and Schima wallichi [38]. 4.…”

Section: Resultsmentioning

confidence: 99%

Malaysian Medicinal Plants’ Potential for Breast Cancer Therapy

Mainasara

Bakar

Linatoc

2018

Asian J Pharm Clin Res

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Objective: This review focused on Malaysian medicinal plants that have been evaluated and pose potentials to treat breast cancer. Results: A total of 105 plants species representing 54 different families and 79 genera were reviewed. 97% of the plants were tested using MCF-7 and MDA-231 breast cancer cell lines and exhibited most significant in vitro anticancer activity, and 3% were tested using another type of breast cancer cell lines. Most of the bioactive compounds of the medicinal plants that exhibited good activity (IC 50 values <120 µg/mL) are a group of phenols, alkaloids, flavonoids, terpenoids, and saponins. Induction of apoptosis was found to be the significant cell death pathway. Methods Conclusion:This article reviews the available literature concerning research on anti-breast cancer plants. Furthermore, identification and characterization of active components and toxicology evaluation also need to be studied in details and also point out their clinical trials.

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Alkenylresorcinols and cytotoxic activity of the constituents isolated from Labisia pumila

Cited by 32 publications

References 34 publications

The effect of particle size and solvent type on the gallic acid yield obtained from Labisia pumila by ultrasonic extraction

The effect of particle size and solvent type on the gallic acid yield obtained from Labisia pumila by ultrasonic extraction

Dietary alkylresorcinols and cancer prevention: a systematic review

Malaysian Medicinal Plants’ Potential for Breast Cancer Therapy

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