Alkyl‐mannoside derivatives: Glycolipids able to form big size aggregates

Abstract

Three different series of alkyl mannoside derivatives have been synthesized, designing the hydrophobic portion to provide different topology to the surfactant and, hence, modulating their aggregation properties. The aggregates formed were characterized using both physical and photophysical methodologies, such as surface tension, dynamic light scattering, and emission of selected fluorescent probes. The non‐ionic sugar surfactants have been widely used in studies of membrane solubilization and protein purification. Indeed, mannoside unit, nonionic and hydrophilic, can be selectively recognized by several lectins, which are proteins present in different membranes. Then, the specific interactions of these derivatives incorporated into synthetic bilayers with lectins have been studied and reported. In this work, monoalkyl derivatives with a presumably conical shape and dialkyl derivatives with cylindrical ones, including also a third family with a hydrophilic spacer were studied. These compounds are able to self‐aggregate to form micelle like structures or bilayers despite their topology. Additionally, they are able to form bilayers, using cosurfactants like cholesterol.

Influence of additive on the aggregation behavior of drug and cationic hydrotrope aniline hydrochloride mixtures: a physicochemical assessment

“…As a result of its simplicity, this model is generally cast-off. By applying the Rubingh model, [51] the micellar compositions of component 1 (X 1 Rub ) were evaluated for all systems using the following fundamental equation:…”

“…Micellar and surface-active properties of self-organizing systems of amphiphilic molecules are significant in an aqueous medium in the arena of the scientific field (fundamental and applied). [1,2] Amphiphiles such as surfactants, bile salts, hydrotropes self-aggregate in aqueous solution or specific solvent and form numerous nanostructured molecules. [2][3][4][5][6][7] These amphiphiles can amend the interfacial assets of the liquid (nonaqueous or aqueous) in which they are existing.…”