Alkylated Isocoumarins from<i>Pituranthos Scoparius</i>

Haba, Hamada; Benkhaled, Mohammed; Massiot, Georges; Long, Christophe; Lavaud, Catherine

doi:10.1080/14786410310001639259

Cited by 18 publications

(6 citation statements)

References 12 publications

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“…Ochratoxin A ( F ), a mycotoxin from Aspergillus ochraceus shows nephrotoxic, hepatotoxic, carcinogenic and teratogenic properties in animals [8]; recently the European Pharmacopoeia introduced a limit test for ochratoxin A in plant material (Method 2.8.22). Scoparine A ( G ) was isolated from the North African medical plant Pituranthos scoparius [9]. …”

Section: Introductionmentioning

confidence: 99%

New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities

HAMPL

2011

Sci. Pharm.

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New isocoumarins were prepared in an efficient way from 2-iodobenzoic acid derivatives and hept-1-yne in a Sonogashira reaction, followed by spontaneous cyclization. Catalytic hydrogenation gave the corresponding dihydroisocoumarins. A 4-chloroisocoumarin was prepared on an alternative pathway. Some of the new compounds showed moderate cytotoxic activities against a human leukemia cell line (HL 60).

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Section: Introductionmentioning

confidence: 99%

New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities

HAMPL

2011

Sci. Pharm.

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“…Nevertheless, in case of several species such as Pituranthos triradiatus, the ants' activity was not observed under the shrub canopies. Such lack of association could be explained by the higher alkaloids concentrations of this plant that opposes nests' establishment [Hamada et al 2004]. The ants positive impact on the arid ecosystem is also evident from the higher ratio of the nests in the complex patches, which indicate their better 'hospitality' rate with compare to the shrubs (Fig.…”

Section: Discussionmentioning

confidence: 97%

Ecological and Microtopographical Impact of Messor Ebeninus and Messor Arenarius Ants on Arid Loess Rangelands of the Northern Negev

Mor‐Mussery

Budovsky

2017

Geogr. environ. sustain.

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Improper land management, such as over-grazing in arid areas, has negative effects on the local ecosystems for both the short and the long term time periods. An effective rehabilitation scheme requires human interference by introducing ecosystem engineering organisms together with activities that encourage the spreading and the reproduction of the local plant and animal species. Most of the former studies in arid lands focused on shrubs as engineering species, and much less on other organisms. The major focus of this study was on assessing the impact of Messor ebeninus and M. arenarius on the micro-topographic patterns of arid areas using unique spatial statistical tools designed solely for this purpose. As a case study, the nests' sizes and their distribution were compared between two adjacent shrublands with similar geographic outlines during 2008 and 2015.One of the shrublands was moderately grazed for the last 20 years (at the far past it was exposed to over-grazing), while the other one is still exposed to over-grazing. The results collected in 2014 at the shrublands and at the adjacent loess area demonstrate the spatial ecosystem ability of the Messor sp. to engineer and beneficially modify their environment by enlarging the water conserving area, increasing the soil fertility and vegetative productivity, and finally accelerating the whole area rehabilitation.

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“…[9] Two isocoumarins have been isolated from the ethyl acetate extract of the root of P. scoparius: 6-hydroxy-5-methoxy-3-propylisocoumarin and 6hydroxy-5,7-dimethoxy-3-propylisocoumarin. [10] Two cinnamic acids (5-O-caffeoylquinic acid and 5-feruloylquinic acid), and 13 known flavonoids (vicenin-2, six quercetin and six isorhamnetin O-glycosylated derivatives) were identified in methanolic and aqueous extracts. [11] Some biological activities have been reported for the extract or essential oils of P. scoparius, such as antioxidant activity [12 -15] and antimicrobial activity.…”

Section: Introductionmentioning

confidence: 99%

“…Five glycosylated flavonoids were isolated in butanolic extract (apigenin 7‐ O ‐glucoside or apigetrin, apigenin 7‐ O ‐rhamnoside, apigenin 6,8‐di‐ C ‐glucoside, isorhamnetin 3‐ O ‐glucoside and apigenin 6,8‐di‐ C ‐glucoside (vicenin‐2)) . Two isocoumarins have been isolated from the ethyl acetate extract of the root of P. scoparius : 6‐hydroxy‐5‐methoxy‐3‐propylisocoumarin and 6‐hydroxy‐5,7‐dimethoxy‐3‐propylisocoumarin . Two cinnamic acids (5‐ O ‐caffeoylquinic acid and 5‐feruloylquinic acid), and 13 known flavonoids (vicenin‐2, six quercetin and six isorhamnetin O ‐glycosylated derivatives) were identified in methanolic and aqueous extracts …”

Section: Introductionmentioning

confidence: 99%

Chemical Variability of the Essential Oil of Pituranthos scoparius from Algeria

Malti

Boussaïd

Belyagoubi

et al. 2018

Chemistry & Biodiversity

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The chemical composition of 93 oil samples from the aerial parts of Pituranthos scoparius, harvested in three regions of Algeria, was investigated by GC-FID, GC/MS and C-NMR. Monoterpene hydrocarbons dominated in association with phenylpropanoids and a chemical variability was found highlighting three clusters. The composition of group I (36 samples) exhibited an atypical composition characterized by a very high contents of 6-methoxyelemicine (13.0 - 59.6%), followed by sabinene (1.1 - 43.0%) and limonene (6.6 - 39.0%), while the samples of group II (12 samples) contained a high content of limonene (9.2 - 44.0%), followed by myristicine (0.0 - 29.4%) and a lower amount of sabinene (0.8 - 2.3%). Group III (45 samples) could be divided in two subgroups. Subgroup SGIIIA was characterized by a very high content of sabinene (28.0 - 55.6%), followed by elemicine (0.0 - 29.1%), while the samples belonging to SGIIIB were characterized by the lower content of sabinene (6.2 - 35.5%) and a significant content of myristicine (1.5 - 32.4%), α-pinene (4.2 - 31.0%) and dill apiole (0.1 - 31.4%). Each harvested region was characterized by a different chemical composition.

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Alkylated Isocoumarins fromPituranthos Scoparius

Abstract: Two isocoumarins have been isolated from the ethyl acetate extract of the root of Pituranthos scoparius: 3-n-propyl-5-methoxy-6-hydroxy-isocoumarin and 3-n-propyl-5,7-dimethoxy-6-hydroxy-isocoumarin. Their structures were assigned by spectral analysis.

Cited by 18 publications

References 12 publications

New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities

New Substituted Isocoumarins and Dihydroisocoumarins and their Cytotoxic Activities

Ecological and Microtopographical Impact of Messor Ebeninus and Messor Arenarius Ants on Arid Loess Rangelands of the Northern Negev

Chemical Variability of the Essential Oil of Pituranthos scoparius from Algeria

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