Alkylated polycyclic aromatic hydrocarbons are the largest contributor to polycyclic aromatic compound concentrations in traditional foods of the Bigstone Cree Nation in Alberta, Canada

Golzadeh, Nasrin; Barst, Benjamin D.; Baker, Janelle Marie; Auger, Josie C.; McKinney, Melissa A.

doi:10.1016/j.envpol.2021.116625

Cited by 27 publications

(17 citation statements)

References 52 publications

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“…The greatest number of PACs detected in the river otter samples was alkylated and LMW compounds. The abundance of alkylated PACs was also observed in traditional foods (i.e., wild plants and animals) consumed by an indigenous community in Alberta, leading to suggestions to include alkylated PACs when measuring PAC levels and conducting PAC exposure assessments in the AOSR (Golzadeh et al, 2021). Alkylated PACs are more hydrophobic than parent PACs, and have greater biota‐sediment accumulation factors, which could account for the higher levels detected within the river otter tissues (Brandt et al, 2002; Wayland et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Microsatellite mutation frequencies in river otters (Lontra Canadensis) from the Athabasca Oil Sands region are correlated to polycyclic aromatic compound tissue burden

Gyasi

Curry

Browning

et al. 2022

Environ and Mol Mutagen

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Mining activities in the Athabasca oil sands region (AOSR) have contributed to an increase of polycyclic aromatic compounds (PACs) locally. However, many PACs found in the AOSR, and the combined effects of PAC mixtures have not been evaluated for genotoxicity in wildlife. Here, we examine whether mutation frequencies in AOSR river otters are correlated to PAC tissue burdens. We used single‐molecule polymerase chain reaction (SM‐PCR) to measure the mutant frequency of unstable DNA microsatellite loci in the bone marrow of wild river otters (n = 11) from the AOSR. Microsatellite mutation frequencies were regressed against liver PAC burden (total, low/high molecular weight [LMW/HMW], and parent/alkylated PACs), and to the distances from where the samples were collected to nearby bitumen upgraders. We found that microsatellite mutation frequency was positively correlated with total liver PAC burden. LMW and alkylated PACs were detected at higher levels and had a stronger positive relationship with mutation frequency than HMW (alkylated and parent) PACs. There were no significant relationships detected between mutation frequency and LMW parent PACs or the distance from bitumen upgraders. Furthermore, pyrogenic and petrogenic signatures suggest PACs in animals with high mutation frequencies were associated with combustion processes; although further investigation is warranted, due to limitations of diagnostic ratio determination with biotic models. Our findings support the hypothesis that PACs found in the AOSR increase mutation frequency in wildlife. Further investigation is required to determine if the elevated PAC levels associated with higher mutation frequency are due to natural exposure or elevated human activity.

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Section: Discussionmentioning

confidence: 99%

Microsatellite mutation frequencies in river otters (Lontra Canadensis) from the Athabasca Oil Sands region are correlated to polycyclic aromatic compound tissue burden

Gyasi

Curry

Browning

et al. 2022

Environ and Mol Mutagen

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“…On the other hand, the manuscripts cited and discussed in this review clearly showed that heterocyclic compounds play an essential role in controlling a phytopathogen such as FOX , being benzothiazole derivatives, the most studied compounds with the highest antifungal activity ( Table 1 ). Some reports have described biological and environmental effects and their potential activity, degradation pathways, and subproducts characterization of synthetic heterocycles such as podophyllotoxin derivatives [ 148 ], rhodamine derivatives and analogs [ 149 ], benzothiazole and benzotriazole derivatives—which have emerged as contaminants in aquatic environments and toxic to aquatic organisms [ 150 , 151 , 152 , 153 ]—and polycyclic (hetero)aromatic hydrocarbons compounds which recently was demonstrated their predominance in contaminated food samples and their relationship with potential toxicity [ 154 ]. However, further studies are necessary to establish these promissory antifungal agents’ potential cytotoxicity and environmental risks.…”

Section: Discussionmentioning

confidence: 99%

A Compendium of the Most Promising Synthesized Organic Compounds against Several Fusarium oxysporum Species: Synthesis, Antifungal Activity, and Perspectives

2021

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Vascular wilt caused by F. oxysporum (FOX) is one of the main limitations of producing several agricultural products worldwide, causing economic losses between 40% and 100%. Various methods have been developed to control this phytopathogen, such as the cultural, biological, and chemical controls, the latter being the most widely used in the agricultural sector. The treatment of this fungus through systemic fungicides, although practical, brings problems because the agrochemical agents used have shown mutagenic effects on the fungus, increasing the pathogen’s resistance. The design and the synthesis of novel synthetic antifungal agents used against FOX have been broadly studied in recent years. This review article presents a compendium of the synthetic methodologies during the last ten years as promissory, which can be used to afford novel and potential agrochemical agents. The revision is addressed from the structural core of the most active synthetic compounds against FOX. The synthetic methodologies implemented strategies based on cyclo condensation reactions, radical cyclization, electrocyclic closures, and carbon–carbon couplings by metal–organic catalysis. This revision contributes significantly to the organic chemistry, supplying novel alternatives for the use of more effective agrochemical agents against F. oxysporum.

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“…56,57 Specically, high temperature cooking methods result in the production of PAHs, which are subsequently deposited on meat surfaces. 58 For example, Golzadeh et al 40 reported that PAHs were higher in smoked moose meat than in non-smoked animal samples. Not only does PAH contamination of raw tissue increase due to cooking, but it can also increase if stored in close proximity to food preparation facilities such as smokehouses.…”

Section: Model Limitationsmentioning

confidence: 99%

A multi-pathway exposure assessment for polycyclic aromatic hydrocarbons among residents in the Athabasca oil sands region, Canada

Zhan

Parajulee

Binnington

et al. 2023

Environ. Sci.: Processes Impacts

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Alkylated polycyclic aromatic hydrocarbons are the largest contributor to polycyclic aromatic compound concentrations in traditional foods of the Bigstone Cree Nation in Alberta, Canada

Cited by 27 publications

References 52 publications

Microsatellite mutation frequencies in river otters (Lontra Canadensis) from the Athabasca Oil Sands region are correlated to polycyclic aromatic compound tissue burden

Microsatellite mutation frequencies in river otters (Lontra Canadensis) from the Athabasca Oil Sands region are correlated to polycyclic aromatic compound tissue burden

A Compendium of the Most Promising Synthesized Organic Compounds against Several Fusarium oxysporum Species: Synthesis, Antifungal Activity, and Perspectives

A multi-pathway exposure assessment for polycyclic aromatic hydrocarbons among residents in the Athabasca oil sands region, Canada

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