Alkylation of Pyrimidine Derivatives with Ethylene Chlorohydrin.

Abstract

In order to obtain new pyrimidine derivatives with possible immunotropic, antiphlogistic, and antiradical action, the alkylation of uracils with ethylene chlorohydrin is investigated. -(KRIVONOGOV, V. P.; MYSHKIN, V. A.; KOZLOVA, G. G.; CHERNYSHENKO, Y. N.; SAVLUKOV, A. I.; PLECHEV, V. V.; IBATULLINA, R. B.; ABDRAKHMANOV, I. B.; SPIRIKHIN, L. V.; Russ.

Experimental and quantum-chemical studies of the reactions of 6-methyluracil with succinic and fumaric acids

“…There are pub lished data on the complex formation of uracils with succinic, fumaric, ascorbic, and citric acids [2]; galac turonic acid [3]; apple pectin and products of its oxi dation [4]; and so on. Complexes of 6 methyluracil with succinic acid [5], 5 hydroxy 6 methyluracil with sodium succinate [6], and 1,3 bis(2 hydroxyethyl) 5 hydroxy 6 methyluracil with fumaric acid [7] exhibit more pronounced antihypoxic activity than their initial components. A complex of 5 hydroxy 6 methyluracil with succinic acid has antioxidant and hepatoprotective effects [8,9].…”