Alkylglycerol Derivatives, a New Class of Skin Penetration Modulators

Abstract

The absorption modulating activity of two alkylglycerol derivatives (batyl and chimyl alcohol) on skin barrier properties was evaluated. Biophysical tests such as transepidermal water loss (TEWL) and attenuated total reflectance–Fourier transform infrared (ATR-FTIR) spectroscopy, as well as in vitro skin permeation studies, were performed in order to determine the effect of these compounds as chemical absorption modulators. Four drugs were used as models: three NSAIDS (diclofenac, naproxen, and piroxicam) and glycyrrhizic acid. The results showed that treatment of the skin with alkylglycerols caused (i) a reduction on the amount of drug permeated; (ii) a reduction in TEWL; and (iii) changes in the ATR-FTIR peaks of stratum corneum lipids, indicative of a more ordered structure. All of these findings confirm that alkyl glycerols have an absorption retarding effect on the drugs tested. Such effects are expected to give rise to important applications in the pharmaceutical and cosmetic sectors, in cases where it is desirable for the drug to remain in the superficial layers of the skin to achieve a local effect.

Mechanism investigation of ethosomes transdermal permeation

“…3B). This transition also involved an increase in the fluidity of the SC lipids that could increase the skin penetration of DPH (Bernal-Chavez et al, 2017). Furthermore, after the SC defatting, the absorption intensity of the symmetric and antisymmetric C—H stretching vibration was significantly weakened (Clancy et al, 1994).…”

1-O-Alkylglycerol Ethers from the Marine Sponge Guitarra abbotti and Their Cytotoxic Activity

“…AGEs have been described to reduce cardiovascular and rheumatoid arthritis risk factors [ 51 ], the side effects of radiotherapy [ 52 , 53 , 54 ], obesity [ 55 , 56 , 57 , 58 ], microglial activation, and a neuropathic pain [ 22 , 59 ]. Additionally, AGEs are effective adjuvants [ 60 , 61 ], which modulate endothelial cell permeability [ 62 ], the immune response in vitro and in vivo [ 63 , 64 , 65 , 66 ], open the blood–brain barrier [ 67 , 68 ], are able to penetrate the skin [ 69 ], and improve sperm motility [ 70 ]. The search for new structural variants of these lipids and the study of their diversity and biological activities represent an interesting aspect of the marine natural products research field.…”

Gas-Phase Catalytic Dehydration of Glycerol with Methanol to Methyl Glyceryl Ethers over Phosphotungstic Acid Supported on Alumina

“…MAGE can be applied in immunostimulatory, antimicrobial, and antitumor applications and anesthesia due to its special biological characteristics . Moreover, it can be used as additives in drugs, , cosmetics, liquid detergents, herbicides, lubricants, and solvents . DAGE and TAGE can be used as fuel additives for diesel, biodiesel, and ethanol gasoline, which can effectively improve fuel quality and reduce pollutant emissions of respirable particles, hydrocarbons, carbon monoxide, and unregulated aldehydes. − …”