Alkylresorcinols Protect the DNA from UV-Damage In Vitro and In Vivo Models

Deryabin, D. G.; Davydova, O. K.; Gryazeva, Irina V.

doi:10.5772/34782

Cited by 2 publications

(4 citation statements)

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“…On the other hand, a great attention has been paid worldwide toward the developments of DNA damageprotecting and DNA-photocleaving agents (Deryabin et al, 2012;Toshima et al, 2002). It has been reported that exposure to UV radiations resulted in serious disorders like erythema, edema, hyperpigmentation, immunosuppression, photoaging, skin cancer, cataract formation and retinal degeneration (Perez-Sanchez et al, 2014;Holloy, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…These radiations lead to the formation of intra-and intermolecular cross-links in DNA besides its degradation (Cai et al, 1998). One of the most common problems encountered among the genetic engineers was inability to find the exact results while performing the gel electrophoresis experiments (Deryabin et al, 2012). A long-time exposure of gel to UV light resulted in the degradation of DNA bands.…”

Section: Introductionmentioning

confidence: 99%

“…A long-time exposure of gel to UV light resulted in the degradation of DNA bands. Therefore, protection of DNA from UV radiations is not only important for the viability of living systems but also important for the effectiveness of DNA-based laboratory techniques (Deryabin et al, 2012). Though in recent years some heterocyclic or non-heterocyclic compounds have been used to protect the DNA from UV-induced damage, developments of newer and efficient protecting agents are still needed (Deryabin et al, 2012 (Toshima et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, protection of DNA from UV radiations is not only important for the viability of living systems but also important for the effectiveness of DNA-based laboratory techniques (Deryabin et al, 2012). Though in recent years some heterocyclic or non-heterocyclic compounds have been used to protect the DNA from UV-induced damage, developments of newer and efficient protecting agents are still needed (Deryabin et al, 2012 (Toshima et al, 2002). The literature survey revealed that compounds bearing pyrazole (Kumar et al, 2014b;Kamal et al, 2014) and thiazole (Li et al, 2004(Li et al, , 2005 nuclei act as efficient DNAphotocleaving agents.…”

Section: Introductionmentioning

confidence: 99%

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Solvent-free synthesis of novel (E)-2-(3,5-dimethyl-4-(aryldiazenyl)-1H-pyrazol-1-yl)-4-arylthiazoles: determination of their biological activity

Kaur¹,

Kumar²,

Beniwal³

et al. 2015

Med Chem Res

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In search of novel biologically active azoles, some new (E)-2-(3,5-dimethyl-4-(aryldiazenyl)-1H-pyrazol-1-yl)-4-arylthiazoles 3a-p have been synthesized via Hantzsch thiazole approach under greener, mild and solvent-free conditions. Structures of all compounds were established on the basis of the rigorous elemental analysis and their IR, NMR ( 1 H, 13 C), COSY, ROSEY, HSQC and HMBC spectral data. To explore the biological potential, all the synthesized compounds were evaluated for their antimicrobial, antioxidant and UV-mediated DNA damageprotective and photocleavage activity. The results of antimicrobial study revealed that among the series, compounds 3g-l were found active selectively against C. albicans. The compound 3l exhibited twofold high antifungal potential in comparison with amphotericin-B, a standard drug against C. albicans. The compound 3k was found equipotent, and 3g-j displayed half of the potential in reference to the standard drug. In UV-induced DNA damage-protecting and photocleavage study, 3j and 3n were found as the most potent DNA damage-protecting and DNA-photocleaving agents, respectively, at 40 lg concentration. The compounds 3d, 3e, 3g, 3i, 3k, 3m and 3o also displayed a significant level of DNA damage-protective potential, whereas 3l and 3p exhibited appreciable DNA photocleavage activity. In the antioxidant study, all compounds were found inactive.

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