2020
DOI: 10.1016/j.eurpolymj.2020.109908
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Alkynyl-functionalized chain-extended PCL for coupling to biological molecules

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Cited by 5 publications
(7 citation statements)
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“…91 Some of the possible methods of functionalization are modifying the polymer back bone, polymerization of functionalized monomers, or copolymerization with other monomers. 92 In the literature functionalization of PCL with polylactide using hydromethyl phosphonic acid as the catalyst, which added end groups required for polycondensation, this lead to the formation of macromolecules with acidic groups. 93 PCL-PEG-PCL triblock copolymers are also synthesized by ROP using DPP as catalyst.…”
Section: Functionalized Pclmentioning
confidence: 99%
See 1 more Smart Citation
“…91 Some of the possible methods of functionalization are modifying the polymer back bone, polymerization of functionalized monomers, or copolymerization with other monomers. 92 In the literature functionalization of PCL with polylactide using hydromethyl phosphonic acid as the catalyst, which added end groups required for polycondensation, this lead to the formation of macromolecules with acidic groups. 93 PCL-PEG-PCL triblock copolymers are also synthesized by ROP using DPP as catalyst.…”
Section: Functionalized Pclmentioning
confidence: 99%
“…Through introduction of chemical groups into PCL, it is possible to modify its properties like degradation rate, hydrophilicity, and crystallinity 91 . Some of the possible methods of functionalization are modifying the polymer back bone, polymerization of functionalized monomers, or copolymerization with other monomers 92 . In the literature functionalization of PCL with polylactide using hydromethyl phosphonic acid as the catalyst, which added end groups required for polycondensation, this lead to the formation of macromolecules with acidic groups 93 .…”
Section: Biological Properties Of Pclmentioning
confidence: 99%
“…Previous work has been reported on the introduction of benzyl and phenyl substitutions to PCL chains as a postmodification via alpha alkylation and click-chemistry (CuAAC and thiol-ene). , However, these approaches have setbacks due to the use of extreme reaction conditions (e.g., strong bases such as LDA), excessive synthetic and purification steps, and lack of synthetic feasibility to control the substituent amount. Furthermore, click approaches demand the addition of one reactant in excess to achieve good yields and require added steps to remove the excess reactants. , To overcome these challenges and control the substituent amount through a one-step synthesis, the caprolactone monomer was modified to achieve Ph-ε-CL prior to the ROP.…”
Section: Resultsmentioning
confidence: 99%
“…Polymers which can degrade over short and medium time spans are important in many different areas of application. Regenerative medicine 1,2 requires biocompatible materials which can be resorbed by the body aer a dened amount of time. Inbuilt degradability can also improve the environmental impact of single-use packaging, 3 when recycling is not possible or not practised.…”
Section: Introductionmentioning
confidence: 99%