All Children with Malignant Rhabdoid Tumors Should Be Treated Initially with Intensive Chemotherapy

Abstract

Malignant rhabdoid tumors (MRT) of soft tissues are aggressive tumors, which can be detected in almost any part of the body. MRT are rare, and very few cases have been reported in the literature. Prognosis of these tumors is extremely poor despite intensive therapy. Some risk factors such as young age or disseminated disease are associated with an aggressive and almost always lethal clinical course. Some clinicians even recommend initial palliative care due to this outcome. We report a case of metastatic MRT in a 6-month-old child with excellent initial response to chemotherapy.

Malignant rhabdoid tumors of soft tissues in children. Literature review

“…Единого подхода в терапии рабдоидных опухолей нет и проанализировать преимущества отдельных режимов ПХТ невозможно из-за малого числа па-циентов, что также наглядно отражено в представ-ленных клинических случаях [53][54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70]. Показано, что на выживаемость влияет использование высоких доз алкилирующих агентов, в том числе антрациклино-вых антибиотиков и актиномицина D [9,80].…”