All Eotaxins CCL11, CCL24 and CCL26 are Increased but to Various Extents in Pulmonary Tuberculosis Patients

Sharifabadi, Abumoslem Rashidi; Hassanshahi, Gholamhossein; Ghalebi, Seyed Razi; Arababadi, Mohammad Kazemi; Khorramdelazad, Hossein; Zainodini, Nahid; Shabani, Ziba

doi:10.7754/clin.lab.2013.121231

Cited by 6 publications

(9 citation statements)

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“…In BMS/AO patients, plasma levels of eotaxin, MCP-1, and VEGF decreased significantly after duloxetine treatment. Although eotaxin levels vary among reports on different diseases (Chalan et al, 2016;Sharifabadi et al, 2014), several reports have suggested that eotaxin levels are increased in individuals with neuropathic pain (Bäckryd et al, 2017;Makker et al, 2017). MCP-1 can contribute to development of chronic pain through central sensitization and microglial activation (Thacker et al, 2009).…”

Section: Plasma Levels Of Neuroinflammation-related Moleculesmentioning

confidence: 99%

Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region

Miyauchi

Tokura

Kimura

et al. 2019

Human Psychopharmacology

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Objective Burning mouth syndrome (BMS) and atypical odontalgia (AO) are examples of somatic symptom disorders with predominant pain around the orofacial region. Neuroinflammation is thought to play a role in the mechanisms, but few studies have been conducted. We aimed to better understand the role of neuroinflammation in the pathophysiology and treatment of BMS/AO. Methods Plasma levels of 28 neuroinflammation‐related molecules were determined in 44 controls and 48 BMS/AO patients both pretreatment and 12‐week post‐treatment with duloxetine. Results Baseline plasma levels of interleukin (IL)‐1β (p < .0001), IL‐1 receptor antagonist (p < .001), IL‐6 (p < .0001), macrophage inflammatory protein‐1β (p < .0001), and platelet‐derived growth factor‐bb (.04) were significantly higher in patients than in controls. Plasma levels of granulocyte macrophage colony stimulating factor were significantly higher in patients than in controls (p < .001) and decreased with treatment (.009). Plasma levels of eotaxin, monocyte chemoattractant protein‐1, and vascular endothelial growth factor decreased significantly with treatment (p < .001, .022, and .029, respectively). Conclusions Inflammatory mechanisms may be involved in the pathophysiology and/or treatment response of somatic symptom disorders with predominant pain around the orofacial region.

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Section: Plasma Levels Of Neuroinflammation-related Moleculesmentioning

confidence: 99%

Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region

Miyauchi

Tokura

Kimura

et al. 2019

Human Psychopharmacology

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“…Eotaxin-1 has not been studied either as a diagnostic nor as a prognostic marker for SBIs. There are publications about levels of Eotaxin-1 in parasitic infections [13], in which patients with tuberculosis had significantly higher levels than controls[14]. There have been no large studies about its use on diagnostics of SBI.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory Cytokine and Chemokine Patterns in Paediatric Patients with Suspected Serious Bacterial Infection

et al. 2019

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Background and objectives: In children, acute infection is the most common cause of visits to the emergency department. Although most of them are self-limiting, mortality due to severe bacterial infections (SBI) in developed countries is still high. When the risk of serious bacterial infection is too high to ignore, yet too low to justify admission and hospital observation, clinicians try to improve diagnostic accuracy by performing various laboratory tests. The aim of the study was to investigate whether an early inflammatory cytokine and chemokine panel can add information in diagnostics of SBI and assessment of efficacy of early therapies in hospitalized children with fever. Methods: This study included 51 children with febrile infections that were admitted to the emergency department (ED). Clinical examination and microbiological and radiological tests were used as reference standards for the definition of SBI. Study population was categorized into two groups: (1) patients with SBI (n = 21); (2) patients without SBI (n = 30). Inflammatory cytokine and chemokine panels were analyzed from the first routine blood samples at hospital admission and after 24 h. Results: Out of 12 cytokines and chemokines, only Eotaxin and granulocyte colony-stimulating factor (G-CSF) had statistically significant differences between groups at the time of inclusion. Receiver operator characteristic analysis to predict SBI showed an area under the curve (AUC) of 0.679 for G-CSF. Conclusions: Analysis of inflammatory cytokine profiles may provide additional information in early diagnostics of SBI.

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“…Eotaxin or CCL11 is a CC-chemokine that signals through the CCR3 receptor. It is produced by IFN-γ -stimulated endothelial cells and TNF-activated monocytes 28 . It has been reported that CCL11, CCL24, and CCL26, which are produced by Th2 cells and other cells that induce Th2 development, are increased in TB patients compared to the controls.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the transcriptional immune biomarkers in peripheral blood from Warao indigenous associate with the infection by Mycobacterium tuberculosis

Araujo

Palacios

Enciso-Moreno

et al. 2019

Rev. Soc. Bras. Med. Trop.

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All Eotaxins CCL11, CCL24 and CCL26 are Increased but to Various Extents in Pulmonary Tuberculosis Patients

Cited by 6 publications

References 0 publications

Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region

Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region

Inflammatory Cytokine and Chemokine Patterns in Paediatric Patients with Suspected Serious Bacterial Infection

Evaluation of the transcriptional immune biomarkers in peripheral blood from Warao indigenous associate with the infection by Mycobacterium tuberculosis

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