All foot and mouth disease virus serotypes initiate protein synthesis at two separate AUGs

Sangar, D. V.; Newton, Susan E; Rowlands, David J.; Clarke, Berwyn

doi:10.1093/nar/15.8.3305

Cited by 106 publications

(82 citation statements)

References 17 publications

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“…In EMCV and TMEV (GDVII strain), this AUG triplet is the initiation codon and ribosomes bind directly to it without scanning (Kaminski et al 1990(Kaminski et al , 1994Pilipenko et al 1994). In FMDV, initiation occurs at this AUG triplet but also, more frequently, at the next downstream AUG triplet (Sangar et al 1987). Very little initiation occurs at the AUG at the 3Ј border of the poliovirus IRES and the initiation codon is ∼160 nucleotides downstream from it.…”

Section: The Mechanism Of Initiation On Picornavirus Iress: the Emcv mentioning

confidence: 99%

Internal ribosome entry sites in eukaryotic mRNA molecules

Hellen¹,

Sarnow²

2001

Genes Dev.

913

844

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Section: The Mechanism Of Initiation On Picornavirus Iress: the Emcv mentioning

confidence: 99%

Internal ribosome entry sites in eukaryotic mRNA molecules

Hellen¹,

Sarnow²

2001

Genes Dev.

913

844

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“…Each of them, as well as some of the processing intermediates, are involved in functions relevant to the virus life cycle in infected cells (reviewed in [25,181]). The L region contains two overlapping proteins Lab and Lb, that result from the translation initiation from each of the two functional AUGs of the polyprotein [23,214]. Lab and Lb catalyse their proteolytic excision from the polyprotein [228,235] and initiate the cleavage of eIF-4F, a component of the cap-binding protein complex [67], leading to the shutoff of host protein synthesis in virus-infected cells.…”

Section: Genomic Organisationmentioning

confidence: 99%

Foot-and-mouth disease virus: a long known virus, but a current threat

et al. 2001

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-Foot-and-mouth disease virus (FMDV) was the first animal virus identified. Since then, FMDV has become a model system in animal virology and a considerable amount of information on its structure, biology and vaccinology has been obtained. However, the disease that this virus produces (FMD) still constitutes one of the main animal health concerns. In this review, we have attempted to summarise the state of the knowledge in different basic and applied areas of FMDV research, with emphasis on those aspects relevant to the control of the disease. FMDV / structure / immunity / vaccine / variability / diagnosisRésumé -Le virus de la fièvre aphteuse : un virus connu de longue date, qui demeure une menace. Le virus de la fièvre aphteuse a été le premier virus animal identifié. Depuis lors, il est devenu un système modèle en virologie animale, et une quantité importante d'informations sur sa structure, sa biologie et sa vaccinologie a été obtenue. Cependant la maladie provoquée par ce virus constitue encore une inquiétude majeure en santé animale. Dans cette revue, nous avons tenté de résumer l'état des connaissances dans différents domaines de recherche, à la fois fondamentaux et appliqués, sur le virus de la fièvre aphteuse, en mettant l'accent sur les aspects relatifs au contrôle de la maladie. virus de la fièvre aphteuse / immunité / vaccin / variabilité / diagnostic

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“…This could prevent efficient initiation at this AUG, forcing a fraction of the initiation complexes to start at the next AUG. Around AUG L, less basepairs can be formed, facilitating initiation at this AUG, as in EMC RNA. The SAT strains predominantly synthesize Lb [24]. In most of the FMDV serotypes basepairing at the two initiation codons is very similar.…”

Section: Basepairing Around Aucymentioning

confidence: 99%

Basepairing with 18S ribosomal RNA in internal initiation of translation

Scheper¹,

Voorma²,

Thomas³

1994

FEBS Letters

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In concert with the translation initiation factors 'rrarzs-acting' factors function specifically during internal initiation on picomaviral mRNAs. Of these trans-acting factors, two have been identified as the La-protein and the polypyrimidine tract binding protein. Within the internal ribosomal entry site on the viral RNA, sequences are present that direct the ribosome to the initiation codon. We suggest that selection of the correct AUG initiation codon occurs through basepairing with a part of 18s ribosomal RNA.

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All foot and mouth disease virus serotypes initiate protein synthesis at two separate AUGs

Cited by 106 publications

References 17 publications

Internal ribosome entry sites in eukaryotic mRNA molecules

Internal ribosome entry sites in eukaryotic mRNA molecules

Foot-and-mouth disease virus: a long known virus, but a current threat

Basepairing with 18S ribosomal RNA in internal initiation of translation

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