All Infants Are at Risk of Developing Medically Attended Respiratory Syncytial Virus Lower Respiratory Tract Infection and Deserve Protection

Hodges, Erin N; White, Meghan; Nelson, Christopher P.

doi:10.1093/infdis/jiac244

Cited by 4 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, enrolled infants had an average (±standard error of the mean [SEM]) gestational age of 38.2 ± 0.5 weeks and an average chronological age of 7.2 ± 0.5 months at the index LRTI encounter (Table 1). As expected, 31 infants' chronological age varied significantly by LRTItesting status (tested: 6.2 ± 0.8 months vs. untested: 8.5 ± 0.7 months, p = 0.03), although this difference was not as pronounced within each setting. RSV-positive infants were on average older than RSV-negative infants (7.6 ± 1.1 vs. 6.8 ± 0.7 months, respectively).…”

Section: Enrolleessupporting

confidence: 69%

Quality of life burden on United States infants and caregivers due to lower respiratory tract infection and adjusting for selective testing: Pilot prospective observational study

Hariharan

Kumar

Glaser

et al. 2023

Health Science Reports

Self Cite

View full text Add to dashboard Cite

Background and Aims: Policymakers need data about the burden of respiratory syncytial virus (RSV) lower respiratory tract infections (LRTI) among infants. This study estimates quality of life (QoL) for otherwise healthy term US infants with RSV-LRTI and their caregivers, previously limited to premature and hospitalized infants, and corrects for selective testing. Methods: The study enrolled infants <1 year with a clinically diagnosed LRTI encounter between January and May 2021. Using an established 0-100 scale, the 36 infants' and caregivers' QoL at enrollment and quality-adjusted life year losses per 1000 LRTI episodes (quality-adjusted life years [QALYs]/1000) were validated and analyzed. Regression analyses examined predictors of RSV-testing and RSVpositivity, creating modeled positives.Results: Mean QoL at enrollment in outpatient (n = 11) LRTI-tested infants (66.4) was lower than that in not-tested LRTI infants (79.6, p = 0.096). For outpatient LRTI infants (n = 23), median QALYs/1000 losses were 9.8 and 0.25 for their caregivers.RSV-positive outpatient LRTI infants (n = 6) had significantly milder QALYs/1000 losses (7.0) than other LRTI-tested infants (n = 5)(21.8, p = 0.030). Visits earlier in the year were more likely to be RSV-positive than later visits (p = 0.023). Modeled RSVpositivity (51.9%) was lower than the observed rate (55.0%). Infants' and caregivers' QALYs/1000 loss were positively correlated (rho = 0.34, p = 0.046), indicating that infants perceived as sicker imposed greater burdens on caregivers. Conclusions:The overall median QALYs/1000 losses for LRTI (9.0) and RSV-LRTI (5.6) in US infants are substantial, with additional losses for their caregivers (0.25 and 0.20, respectively). These losses extend equally to outpatient episodes. This study is

show abstract

Section: Enrolleessupporting

confidence: 69%

Quality of life burden on United States infants and caregivers due to lower respiratory tract infection and adjusting for selective testing: Pilot prospective observational study

Hariharan

Kumar

Glaser

et al. 2023

Health Science Reports

Self Cite

View full text Add to dashboard Cite

show abstract

“…Respiratory Syncytial Virus (RSV) has been recognized as one of the commonest causes of childhood acute upper and/or lower respiratory illnesses which responsible for about 50% to 90% of bronchiolitis cases and about 50% of pneumonia cases among the pediatric population worldwide (3)(4)(5). Nearly 45% of these cases require hospital admission with most death occur in infants less than 6 months of age (6). RSV infection in children is almost always symptomatic, illness ranging from barely notice, or mild nonspecific symptoms to severe and sometimes fatal disease of the lower airways (7).…”

Section: Introductionmentioning

confidence: 99%

Molecular Detection of Respiratory Syncytial Virus in Infants and Young Children by the Conventional Reverse Transcriptase Polymerase Chain Reaction

2023

JPTCP

View full text Add to dashboard Cite

Background: At the peak of the viral season, World Health Organization ranked respiratory syncytial virus (RSV) as a major cause of acute respiratory infections in more than 60% of children and more than 80% of infants younger than one year. The current study is the first in the governorate of Was it to investigate respiratory syncytial virus subtypes. The objectives of the study were to estimate the frequency of respiratory syncytial virus in children ≤5 years old and to recognize some potential risk factors that might be associated with respiratory tract infections. Methodology: A cross sectional study with conventional reverse transcription polymerase chain reaction was performed on nasopharyngeal swabs from 158 pediatric patients. We compared the demographic and clinical characteristics of the patients aged 15 days to 60 months hospitalised with RTIs or seen at private clinics (cases, n = 158) and control children (n = 40) with non-respiratory symptoms during the respiratory season of 2021-2022. Pearson's chi-square (x²) model was applied, and P ≤ 0.05 was considered significant. Results: RSV nucleic acid was detected in 15 (9.49%) of the 158 clinical specimens after amplification of the F gene. The identity of these amplified fragments was confirmed as human respiratory syncytial virus subtype B by sequencing. Except the clinical presentation there was no overall association between negative and positive cases while breast feeding and family history of the same condition when comparing the control and positive cases showed statistically significant. Conclusions: conventional PCR was successfully detected the subtype B of h RSV while it may not the appropriate PCR type for subtype A detecting or that the RSVB was the only subtype circulated in 2021-2022 winter.

show abstract

Trends in RSV testing patterns among infants presenting with bronchiolitis: Results from four United States health systems, 2015-2023

Blatt,

Suh,

Walter

et al. 2024

Annals of Epidemiology

View full text Add to dashboard Cite

All Infants Are at Risk of Developing Medically Attended Respiratory Syncytial Virus Lower Respiratory Tract Infection and Deserve Protection

Cited by 4 publications

References 33 publications

Quality of life burden on United States infants and caregivers due to lower respiratory tract infection and adjusting for selective testing: Pilot prospective observational study

Quality of life burden on United States infants and caregivers due to lower respiratory tract infection and adjusting for selective testing: Pilot prospective observational study

Molecular Detection of Respiratory Syncytial Virus in Infants and Young Children by the Conventional Reverse Transcriptase Polymerase Chain Reaction

Trends in RSV testing patterns among infants presenting with bronchiolitis: Results from four United States health systems, 2015-2023

Contact Info

Product

Resources

About