All-Optical Planar Polymer Waveguide-Based Biosensor Chip Designed for Smartphone-Assisted Detection of Vitamin D

Walter, Johanna‐Gabriela; Alwis, Lourdes S. M.; Roth, Bernhard; Bremer, Kort

doi:10.3390/s20236771

Cited by 34 publications

(20 citation statements)

References 25 publications

(36 reference statements)

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“…The system proposed by Bremer and Roth was adapted in [ 105 ] to the detection of SPR in a planar waveguide configuration. Here, the fiber sensor is replaced by a tapered waveguide geometry with an initial thickness of 1200 μm, reduced to 200 μm in the proximity of the sensor.…”

Section: Smartphone Fiber Optic Sensorsmentioning

confidence: 99%

Cost-Effective Fiber Optic Solutions for Biosensing

et al. 2022

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In the last years, optical fiber sensors have proven to be a reliable and versatile biosensing tool. Optical fiber biosensors (OFBs) are analytical devices that use optical fibers as transducers, with the advantages of being easily coated and biofunctionalized, allowing the monitorization of all functionalization and detection in real-time, as well as being small in size and geometrically flexible, thus allowing device miniaturization and portability for point-of-care (POC) testing. Knowing the potential of such biosensing tools, this paper reviews the reported OFBs which are, at the moment, the most cost-effective. Different fiber configurations are highlighted, namely, end-face reflected, unclad, D- and U-shaped, tips, ball resonators, tapered, light-diffusing, and specialty fibers. Packaging techniques to enhance OFBs’ application in the medical field, namely for implementing in subcutaneous, percutaneous, and endoscopic operations as well as in wearable structures, are presented and discussed. Interrogation approaches of OFBs using smartphones’ hardware are a great way to obtain cost-effective sensing approaches. In this review paper, different architectures of such interrogation methods and their respective applications are presented. Finally, the application of OFBs in monitoring three crucial fields of human life and wellbeing are reported: detection of cancer biomarkers, detection of cardiovascular biomarkers, and environmental monitoring.

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Section: Smartphone Fiber Optic Sensorsmentioning

confidence: 99%

Cost-Effective Fiber Optic Solutions for Biosensing

et al. 2022

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“…Several LoC-based applications, as can be found in literature, do not need to treat the analyte [ 55 , 56 , 57 ] but simply perform the detection by using electrochemical [ 58 , 59 , 60 ], mechanical [ 61 ], or optical methods [ 21 , 62 , 63 , 64 ]. Among these, the optical detection has been the most widely used technique for quantitative analysis due to its robustness and sensitivity [ 2 ].…”

Section: Evaluation Of System Performancesmentioning

confidence: 99%

Thin-Film-Based Multifunctional System for Optical Detection and Thermal Treatment of Biological Samples

et al. 2022

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In this work, we present a multifunctional Lab-on-Chip (LoC) platform based on hydrogenated amorphous silicon sensors suitable for a wide range of application in the fields of biochemical and food quality control analysis. The proposed system includes a LoC fabricated on a 5 cm × 5 cm glass substrate and a set of electronic boards for controlling the LoC functionalities. The presented Lab-on-Chip comprises light and temperature sensors, a thin film resistor acting as a heating source, and an optional thin film interferential filter suitable for fluorescence analysis. The developed electronics allows to control the thin film heater, a light source for fluorescence and absorption measurements, and the photosensors to acquire luminescent signals. All these modules are enclosed in a black metal box ensuring the portability of the whole platform. System performances have been evaluated in terms of sensor optical performances and thermal control achievements. For optical sensors, we have found a minimum number of detectable photons of 8 × 104 s−1·cm−2: at room temperature, 1.6 × 106 s−1·cm−2: in presence of fluorescence excitation source, and 2.4 × 106 s−1·cm−2· at 90 °C. From a thermal management point of view, we have obtained heating and cooling rates both equal to 2.2 °C/s, and a temperature sensor sensitivity of about 3 mV/°C even in presence of light. The achieved performances demonstrate the possibility to simultaneously use all integrated sensors and actuators, making promising the presented platform for a wide range of application fields.

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“…Derived optical biosensors are integrated into microfluidic platforms adapted to measurements in a liquid medium, which results in the fabrication of miniaturized and portable sensors. Table 1 illustrates several examples of such biosensors cited in the literature [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ], and many other examples can be found in recent reviews [ 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Setting Up and Assessing a New Micro-Structured Waveguiding Fluorescent Architecture on Glass Entirely Elaborated by Sol–Gel Processing

et al. 2022

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Channel waveguides with diffraction gratings at their input and output for light injection and extraction, respectively, are extensively exploited for optical and photonic applications. In this paper, we report for the first time on such an architecture on glass entirely elaborated by sol–gel processing using a titanium-oxide-based photoresist that can be imprinted through a single photolithography step. This work is more particularly focused on a fluorescent architecture including channel waveguides doped with a ruthenium-complex fluorophore (tris(4,7-diphenyl-1,10-phenanthroline)ruthenium(II), Rudpp). The study demonstrates that this original sol–gel micro-structured architecture is well adapted to efficient channel waveguide/diffraction grating coupling and propagation of the fluorescence excitation and emission signals in the core of the channel waveguide. It demonstrates, in particular, a relatively large tolerance of several degrees in the angular injection fiber positioning and an important axial and vertical fiber spatial positioning tolerance of more than 100 µm at the Rudpp emission wavelength. The measurements also indicate that, in the conditions tested in this work, a Rudpp concentration of around 0.1 mM and a channel waveguide length of 2 to 5 mm offer the best trade-off in terms of excitation signal propagation and emission signal detection. This work constitutes a promising preliminary step toward the integration of our architecture into a microfluidic platform for fluorescence measurement in a liquid medium and waveguiding configuration.

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All-Optical Planar Polymer Waveguide-Based Biosensor Chip Designed for Smartphone-Assisted Detection of Vitamin D

Cited by 34 publications

References 25 publications

Cost-Effective Fiber Optic Solutions for Biosensing

Cost-Effective Fiber Optic Solutions for Biosensing

Thin-Film-Based Multifunctional System for Optical Detection and Thermal Treatment of Biological Samples

Setting Up and Assessing a New Micro-Structured Waveguiding Fluorescent Architecture on Glass Entirely Elaborated by Sol–Gel Processing

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