All-photonic kinase inhibitors: light-controlled release-and-report inhibition

Fleming, Cassandra L.; Benitez-Martin, Carlos; Bernson, Elin; Xu, Yongjin; Kristenson, Linnea; Inghardt, Tord; Lundbäck, Thomas; Thorén, Fredrik B.; Grøtli, Morten; Andréasson, Joakim

doi:10.1039/d4sc00390j

Chem. Sci.

2024

DOI: 10.1039/d4sc00390j

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All-photonic kinase inhibitors: light-controlled release-and-report inhibition

Cassandra L. Fleming,

Carlos Benitez-Martin,

Elin Bernson

et al.

Abstract: An all-photonic method is described, in which (i) the release of an active kinase inhibitor is controlled externally with light; and (ii) fluorescence is employed to report both the release and binding of the inhibitor to its corresponding target.

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Coumarin‐Derived Caging Groups in the Spotlight: Tailoring Physiochemical and Photophysical Properties

Clotworthy,

Dawson,

Johnstone

et al. 2024

ChemPlusChem

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The development of light‐responsive molecular tools enables spatiotemporal control of biochemical processes with superior precision. Amongst these molecular tools, photolabile caging groups are employed to prevent critical binding interactions between a bioactive molecule and its corresponding target. Only upon irradiation with light, the bioactive is released in its ‘active’ form and is now readily available to bind to its target. Coumarin‐derived caging groups constitute one of the most popular classes of photolabile protecting groups, due to their facile synthetic accessibility, ease of tuning photophysical properties via structural modification and rapid photolysis reactions. Herein, we highlight the recent progress made on the development of coumarin‐derived caging groups, in which the red‐shifting of absorption spectra, improving aqueous solubility and tailoring sub‐cellular localisation has been of particular interest.

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Coumarin‐Derived Caging Groups in the Spotlight: Tailoring Physiochemical and Photophysical Properties

Clotworthy,

Dawson,

Johnstone

et al. 2024

ChemPlusChem

View full text Add to dashboard Cite

show abstract

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All-photonic kinase inhibitors: light-controlled release-and-report inhibition

Abstract: An all-photonic method is described, in which (i) the release of an active kinase inhibitor is controlled externally with light; and (ii) fluorescence is employed to report both the release and binding of the inhibitor to its corresponding target.

Cited by 1 publication

References 46 publications

Coumarin‐Derived Caging Groups in the Spotlight: Tailoring Physiochemical and Photophysical Properties

Coumarin‐Derived Caging Groups in the Spotlight: Tailoring Physiochemical and Photophysical Properties

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