All-polymer silk-fibroin optical planar waveguides

Prajzler, Václav; Arif, Sara; Min, Kyungtaek; Kim, Sunghwan; Nekvindová, Pavla

doi:10.1016/j.optmat.2021.110932

Cited by 13 publications

(9 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The resulting implant adhesion (shear) strength remains to be improved by a factor of 10–100× for load-bearing applications, but may suit less-strenuous, non-load-bearing applications. Our future work will continue to improve the adhesion strength of light-activated bone implants while expanding the technology to the latest materials available for transparent waveguides. − In vivo investigation of CaproGlu has previously demonstrated moderate immunological response . CaproGlu was also assessed by OECD-regulated in vitro tests, which demonstrated no sensitization or genotoxic effect .…”

Section: Results and Discussionmentioning

confidence: 99%

Fixation of Transparent Bone Pins with Photocuring Biocomposites

Wicaksono

Toni

Tok

et al. 2021

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Bone fractures are in need of rapid fixation methods, but the current strategies are limited to metal pins and screws, which necessitate secondary surgeries upon removal. New techniques are sought to avoid surgical revisions, while maintaining or improving the fixation speed. Herein, a method of bone fixation is proposed with transparent biopolymers anchored in place via light-activated biocomposites based on expanding CaproGlu bioadhesives. The transparent biopolymers serve as a UV light guide for the activation of CaproGlu biocomposites, which results in evolution of molecular nitrogen (from diazirine photolysis), simultaneously expanding the covalently cross-linked matrix. Osseointegration additives of hydroxyapatite or Bioglass 45S5 yield a biocomposite matrix with increased stiffness and pullout strength. The structure−property relationships of UV joules dose, pin diameter, and biocomposite additives are assessed with respect to the apparent viscosity, shear modulus, spatiotemporal pin curing, and lap-shear adhesion. Finally, a model system is proposed based on ex vivo investigation with bone tissue for the exploration and optimization of UV-active transparent biopolymer fixation.

show abstract

Section: Results and Discussionmentioning

confidence: 99%

Fixation of Transparent Bone Pins with Photocuring Biocomposites

Wicaksono

Toni

Tok

et al. 2021

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

“…Furthermore, SF hydrogels possesses various key properties for biomedical applications, such as its inherent biocompatibility, biodegradability and ease of manipulation [ [71] , [72] , [73] ]. Optical losses of SF exhibit as low as 0.25 dB/cm at 846 nm and 0.25 at 1549 nm, suggesting a strong potential for waveguiding mediums [ 74 ]. Through the different extraction methods of SF such as physically [ 75 ], chemically [ 76 ], enzymatic [ 77 ] or a combination of methods [ 78 ], waveguiding SF hydrogels were developed over the years.…”

Section: Optical Hydrogelsmentioning

confidence: 99%

Hydrogel for light delivery in biomedical applications

Yew,

Chee,

Lin

et al. 2024

Bioactive Materials

View full text Add to dashboard Cite

“…Degummed SF fibers can be dissolved through different techniques to obtain an aqueous SF solution which can be further regenerated to develop materials presenting disparate mechanical properties, e.g., films, hydrogels, porous structures, and nanoparticles [19]. The heterogenicity and tunability of SF-based materials have gained increasing attention for applications not only in biomedicine and biotechnology but also in optical and electronics fields due to their remarkable chemo-physical properties [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Silk Fibroin Materials: Biomedical Applications and Perspectives

De Giorgio,

Matera,

Vurro

et al. 2024

Bioengineering

View full text Add to dashboard Cite

The golden rule in tissue engineering is the creation of a synthetic device that simulates the native tissue, thus leading to the proper restoration of its anatomical and functional integrity, avoiding the limitations related to approaches based on autografts and allografts. The emergence of synthetic biocompatible materials has led to the production of innovative scaffolds that, if combined with cells and/or bioactive molecules, can improve tissue regeneration. In the last decade, silk fibroin (SF) has gained attention as a promising biomaterial in regenerative medicine due to its enhanced bio/cytocompatibility, chemical stability, and mechanical properties. Moreover, the possibility to produce advanced medical tools such as films, fibers, hydrogels, 3D porous scaffolds, non-woven scaffolds, particles or composite materials from a raw aqueous solution emphasizes the versatility of SF. Such devices are capable of meeting the most diverse tissue needs; hence, they represent an innovative clinical solution for the treatment of bone/cartilage, the cardiovascular system, neural, skin, and pancreatic tissue regeneration, as well as for many other biomedical applications. The present narrative review encompasses topics such as (i) the most interesting features of SF-based biomaterials, bare SF’s biological nature and structural features, and comprehending the related chemo-physical properties and techniques used to produce the desired formulations of SF; (ii) the different applications of SF-based biomaterials and their related composite structures, discussing their biocompatibility and effectiveness in the medical field. Particularly, applications in regenerative medicine are also analyzed herein to highlight the different therapeutic strategies applied to various body sectors.

show abstract

All-polymer silk-fibroin optical planar waveguides

Cited by 13 publications

References 39 publications

Fixation of Transparent Bone Pins with Photocuring Biocomposites

Fixation of Transparent Bone Pins with Photocuring Biocomposites

Hydrogel for light delivery in biomedical applications

Silk Fibroin Materials: Biomedical Applications and Perspectives

Contact Info

Product

Resources

About