All-small-molecule dynamic covalent gels with antibacterial activity by boronate-tannic acid gelation

Cheng, Xuejing; Li, Mengyu; Wang, Hui; Cheng, Yiyun

doi:10.1016/j.cclet.2019.07.013

Cited by 76 publications

(39 citation statements)

References 37 publications

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“…Thanks to the antibacterial, antiinflammatory, antioxidant, and anticancer properties as well as the universal adhesion capability of natural tea polyphenols, polyphenols are fast becoming a popular class of molecules that are attracting more researchers to build various materials for bioimaging, therapeutic delivery, and other biomedical applications. [236][237][238][239][240][241][242][243][244][245][246][247][248][249][250][251] Moreover, inspired by the coordination interactions between various metal ions and polyphenols, researchers have also provided a number of functional MPNs to engineer multifunctional nanosystems. [252][253][254][255][256][257][258][259] Here, we have reviewed the structures and classification of natural polyphenols, the synthesis and properties of the polyphenol-containing nanomaterials, and various biomedical applications of polyphenol-based nanosystems.…”

Section: Discussionmentioning

confidence: 99%

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

et al. 2021

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Polyphenols, the phenolic hydroxyl group-containing organic molecules, are widely found in natural plants and have shown beneficial effects on human health. Recently, polyphenol-containing nanoparticles have attracted extensive research attention due to their antioxidation property, anticancer activity, and universal adherent affinity, and thus have shown great promise in the preparation, stabilization, and modification of multifunctional nanoassemblies for bioimaging, therapeutic delivery, and other biomedical applications. Additionally, the metal−polyphenol networks, formed by the coordination interactions between polyphenols and metal ions, have been used to prepare an important class of polyphenol-containing nanoparticles for surface modification, bioimaging, drug delivery, and disease treatments. By focusing on the interactions between polyphenols and different materials (e.g., metal ions, inorganic materials, polymers, proteins, and nucleic acids), a comprehensive review on the synthesis and properties of the polyphenol-containing nanoparticles is provided. Moreover, the remarkable versatility of polyphenol-containing nanoparticles in different biomedical applications, including biodetection, multimodal bioimaging, protein and gene delivery, bone repair, antibiosis, and cancer theranostics is also demonstrated. Finally, the challenges faced by future research regarding the polyphenol-containing nanoparticles are discussed.

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Section: Discussionmentioning

confidence: 99%

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

et al. 2021

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“…Natural polyphenols are a class of antioxidants with potent anti-inflammatory, anticancer, and antibacterial properties. [34][35][36][37][38][39][40][41][42][43][44] These naturally occurring compounds have high binding affinities with a variety of biomolecules such as proteins and nucleic acids via a combination of hydrogen bonding and hydrophobic interactions. 34,36,45,46 In a recent study, we successfully condensed unmodified siRNA molecules into stable and negatively charged nanoparticles using a natural polyphenol (-)-epigallocatechin-3-O-gallate (EGCG).…”

Section: Introductionmentioning

confidence: 99%

Natural Polyphenol Inspired Polycatechols for Efficient siRNA Delivery

et al. 2020

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There is a continuing quest to rationally fabricate polymeric biomaterials with both high transfection efficiency and minimal toxicity for the emerging opportunities in small interfering RNA (siRNA) delivery. Recently, this goal was promoted highly by developing a robust and efficient strategy to facilitate polymer-mediated RNAi using natural polyphenols with multiple phenol groups that could condense siRNA effectively into negatively charged nanoparticles (NPs). Further coating of these NPs with cationic polymers of low molecular weight enabled their intracellular siRNA delivery. Inspired by the structural and functional features of natural polyphenols, we aimed to further the development of low molecular weight polycatechols as a new class of efficient and biocompatible polymers for siRNA delivery in our current study. The fabricated polycatechols have benefits of requiring only one-step fabrication toward efficient siRNA nanoformulations. Moreover, they could deliver siRNA into cells and silence target genes both in vitro and in vivo. The resulting polycatechol/siRNA formulations were also functionally competent, demonstrating a successful, profound downregulation of a proinflammatory enzyme to attenuate chronic intestinal inflammation in an intestinal injury model. This study provides a new approach in chemistry for the development of efficient synthetic polymers for therapeutic siRNA delivery.

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“…Tannic acid is known to destabilize the bacteria membrane and consequently tannic acid/borate gels show antibacterial activity towards E. coli. [29] Another way to insert a Schiff base in a hydrogel is to use polyethylene glycol (PEG). Bu and co-workers [27c] created hydrogels with three different PEGs: 4-arm-PEG-NH 2 , 4-arm-PEG-NHS, and 4-arm-PEG-CHO loaded with vancomycin, a firstgeneration glycopeptide antibiotic ( Figure 5).…”

Section: Ph-responsive Hydrogelsmentioning

confidence: 99%

New Smart Antimicrobial Hydrogels, Nanomaterials, and Coatings: Earlier Action, More Specific, Better Dosing?

Tallet

Gribova

Ploux

et al. 2020

Adv Healthcare Materials

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To fight against antibiotic‐resistant bacteria adhering and developing on medical devices, which is a growing problem worldwide, researchers are currently developing new “smart” materials and coatings. They consist in delivery of antimicrobial agents in an intelligent way, i.e., only when bacteria are present. This requires the use of new and sophisticated tools combining antimicrobial agents with lipids or polymers, synthetic and/or natural. In this review, three classes of innovative materials are described: hydrogels, nanomaterials, and thin films. Moreover, smart antibacterial materials can be classified into two groups depending on the origin of the stimulus used: those that respond to a nonbiological stimulus (light, temperature, electric and magnetic fields) and those that respond to a biological stimulus related to the presence of bacteria, such as changes in pH or bacterial enzyme secretion. The bacteria presence can induce a pH change that constitutes a first potential biological trigger allowing the system to become active. A second biological trigger signal consists in enzymes produced by bacteria themselves. A complete panel of recent studies will be given focusing on the design of such innovative smart materials that are sensitive to biological triggers.

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All-small-molecule dynamic covalent gels with antibacterial activity by boronate-tannic acid gelation

Cited by 76 publications

References 37 publications

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Natural Polyphenol Inspired Polycatechols for Efficient siRNA Delivery

New Smart Antimicrobial Hydrogels, Nanomaterials, and Coatings: Earlier Action, More Specific, Better Dosing?

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