All-solid-state chip utilizing molecular imprinted polymer for erythromycin detection in milk samples: Printed circuit board-based potentiometric system

Abstract

Detection of erythromycin (ERY) residues in commercial milk samples is crucial for the safety assessment. Herein, a printed circuit board was patterned as a feasible miniaturized potentiometric sensor for ERY determination in dairy samples. The proposed chip design fits to a 3.5-mm female audio plug to facilitate the potential measurements of working electrode versus reference one in this all-solid-state system. The sensor utilizes molecular imprinted polymer (MIP) for the selective recognition of the studied drug in such challenging matrix. The electrode stability is achieved through the addition of poly (3,4-ethylenedioxythiophene) nano-dispersion on its surface. The proposed device detects down to 6.6 × 10−8 M ERY with a slope of 51 mV/decade in the 1 × 10−7–1 × 10−3 M range. The results display high accuracy (99.9% ± 2.6) with satisfactory relative standard deviation for repeatability (1.6%) and reproducibility (5.0%). The effect of common antibiotic classes, namely, amphenicols, beta-lactams, fluoroquinolones, sulfonamides, and tetracyclines, can be neglected as evidenced by their calculated binding capacities towards the proposed MIP. The calculated selectivity coefficients also show a good electrode performance in the presence of naturally present inorganic ions allowing its application to different milk samples. Graphical abstract

Response surface optimised photocatalytic degradation and quantitation of repurposed COVID-19 antibiotic pollutants in wastewaters; towards greenness and whiteness perspectives

“…Concerns about repurposed antibiotic consumption increased; accordingly, they found their way through sewage, industrial and hospital effluents into receiving environment waters (Hayden et al 2022;Wang et al 2022). There is an environmental risk of bioaccumulation of antibiotics to levels which would cause bacterial resistance, endocrine disturbance and genotoxic effects (Elbalkiny et al 2020;Elbalkiny and Yehia 2022;Tantawy et al 2023).…”