All-terrain droplet actuation

Abdelgawad, Mohamed; Freire, Sergio L. S.; Yang, Hao; Wheeler, Aaron R.

doi:10.1039/b801516c

Cited by 167 publications

(141 citation statements)

References 36 publications

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“…A variety of droplet actuation methods have been conducted, including the thermal Marangoni effect, 16 photosensitive surface treatment, 17 surface acoustic wave, 18 liquid dielectrophoresis, 19 and EW. [20][21][22][23] Of all those techniques, EW has drawn the most interest due to its simplicity and fast response.…”

Section: Introductionmentioning

confidence: 99%

Electrowetting on a lotus leaf

2009

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Electrowetting on dielectrics has been widely used to manipulate and control microliter or nanoliter liquids in micro-total-analysis systems and laboratory on a chip. We carried out experiments on electrowetting on a lotus leaf, which is quite different from the equipotential plate used in conventional electrowetting. This has not been reported in the past. The lotus leaf is superhydrophobic and a weak conductor, so the droplet can be easily actuated on it through electrical potential gradient. The capillary motion of the droplet was recorded by a high-speed camera. The droplet moved toward the counterelectrode to fulfill the actuation. The actuation speed could be of the order of 10 mm/s. The actuation time is of the order of 10 ms.

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Section: Introductionmentioning

confidence: 99%

Electrowetting on a lotus leaf

2009

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“…The 2 ϫ 2 SMF devices facilitate the actuation and mixing of four different oligonucleotide samples, labeled with different reporter and quencher fluorochromes, and allowed us to study base pair complementarities using the principles of fluorescence resonance energy transfer method. Other prominent examples of DNA assays demonstrated on SMF platforms ͑which utilize the widely popular phenomena of electrowetting for sample manipulation͒ include DNA ligation, 36 nucleic acid extraction and purification, 37 and DNA amplification through polymerase chain reaction ͑PCR͒. 38,39 In a recent report, Malic et al 40 presented an electrowetting based SMF system, configured for patterning substrates ͑referred as biochips͒ with an array of oligonucleotides.…”

Section: A On-chip Dna Analysismentioning

confidence: 99%

Liquid dielectrophoresis and surface microfluidics

Kaler

Prakash²,

Chugh³

2010

Biomicrofluidics

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Liquid dielectrophoresis ͑L-DEP͒, when deployed at microscopic scales on top of hydrophobic surfaces, offers novel ways of rapid and automated manipulation of very small amounts of polar aqueous samples for microfluidic applications and development of laboratory-on-a-chip devices. In this article we highlight some of the more recent developments and applications of L-DEP in handling and processing of various types of aqueous samples and reagents of biological relevance including emulsions using such microchip based surface microfluidic ͑SMF͒ devices. We highlighted the utility of these devices for on-chip bioassays including nucleic acid analysis. Furthermore, the parallel sample processing capabilities of these SMF devices together with suitable on-or off-chip detection capabilities suggest numerous applications and utility in conducting automated multiplexed assays, a capability much sought after in the high throughput diagnostic and screening assays.

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“…Droplet-based microfluidic systems can be fundamentally categorized into two basic designs: channel-based microfluidics in which the actuation occurs via liquid flows within microfabricated devices and the planar-surface approach where the actuation occurs through electrowetting or dielectrophoresis [4,9]. The planar-surface approach, sometimes called digital microfluidics, enables manipulation of discrete droplets on an array of electrodes [10]. In this paper, we will focus exclusively on recent advancements in channel-based systems.…”

Section: Introductionmentioning

confidence: 99%

Droplet microfluidics: A tool for biology, chemistry and nanotechnology

Mashaghi

Abbaspourrad

Weitz

et al. 2016

TrAC Trends in Analytical Chemistry

322

188

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The ability to perform laboratory operations on small scales using miniaturized devices provides numerous benefits, including reduced quantities of reagents and waste as well as increased portability and controllability of assays. These operations can involve reaction components in the solution phase and as a result, their miniaturization can be accomplished through microfluidic approaches. One such approach, droplet microfluidics, provides a high-throughput platform for a wide range of assays and approaches in chemistry, biology and nanotechnology. We highlight recent advances in the application of droplet microfluidics in chipbased technologies, such as single-cell analysis tools, small-scale cell cultures, in-droplet chemical synthesis, high-throughput drug screening, and nanodevice fabrication.

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All-terrain droplet actuation

Cited by 167 publications

References 36 publications

Electrowetting on a lotus leaf

Electrowetting on a lotus leaf

Liquid dielectrophoresis and surface microfluidics

Droplet microfluidics: A tool for biology, chemistry and nanotechnology

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