All That Glitters Isn't Gold

Obasogie, Osagie K.; Duster, Troy

doi:10.1002/j.1552-146x.2011.tb00135.x

Cited by 3 publications

(3 citation statements)

References 4 publications

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“…Firstly, our Monte Carlo model includes no particlemovement-related information and might be oversimplified. Due to the short tether length used in this study, it could be that substrate-particle interactions like hydrodynamic effects [13], [14], any effects related to the DLVO theory [15], [16], volume exclusion effects [17] and/or unknown effects that cannot be explained yet [18] cause the AuNPs to behave differently than expected from simulations.…”

Section: Resultsmentioning

confidence: 99%

DNA-Origami Enabled Distance-Dependent Sensing

2022

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Localized surface plasmon resonance is a popular optical detection technique due to its ease of use. However, the main issues of this technique are its selectivity and sensitivity towards (small) single molecules. We address these challenges by introducing a distance-dependent plasmonic sensing method based on a gold nanoparticle (AuNP) tethered by a single DNA hairpin to a gold film (Au-film). The plasmonic properties of a AuNP enable us to distinguish the z-height of the particle. In the absence of a target sequence, the hairpin keeps the AuNP close to the Au-film, while hybridization with a target sequence results in an extended state of the DNA tether. We experimentally confirmed the assembly of this sensor and by simulations, predicted the plasmonic signal of the two states. Finally, we showed experimental results as proof of concept of our sensing method.

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Section: Resultsmentioning

confidence: 99%

DNA-Origami Enabled Distance-Dependent Sensing

2022

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“…In law, as noted above, we are witnessing claims to be able to garner physiognomic data from the DNA, a far cry from the repeated nonsense that DNA is just like another fingerprint. Quite to the contrary, DNA permits familial searching of relatives in a heavily racialized database (Obasogie and Duster 2011). Where are we headed in medicine?…”

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confidence: 99%

Is personalized medicine different? (Reinscription: the sequel) A response to Troy Duster

Prainsack

2015

British Journal of Sociology

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confidence: 99%

Response to comments on ‘A post‐genomic surprise’

Duster

2015

British Journal of Sociology

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In response to the seven authors who offered comments on my paper, I have tried to synthesize and distill common themes. Foremost among them is the charge to look forward, not only to consider probable developments and implications for how this 'molecular reinscription of race' will unfold in forensics and clinical medicine, but as well to suggest how the discipline of Sociology can and should respond. But as several of the commentators noted, this is not just a matter for a single discipline, but should be fertile ground for coordinated empirical investigation by such fields as the Social Studies of Science, Anthropology of Medicine, and Critical Race Theory. For sociologically informed reasons, social scientists should be wary of the unanticipated consequences of collaboration with human molecular geneticists who come to the table deploying databases with pre-fabricated categories of race, thereby poised to provide genetic explanations of social outcomes based upon race and ethnicity. A cautionary note is provided explaining how and why some joint projects are advised, some are ill-advised.

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All That Glitters Isn't Gold

Cited by 3 publications

References 4 publications

DNA-Origami Enabled Distance-Dependent Sensing

DNA-Origami Enabled Distance-Dependent Sensing

Is personalized medicine different? (Reinscription: the sequel) A response to Troy Duster

Response to comments on ‘A post‐genomic surprise’

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