Allamanda cathartica: A Review of the Phytochemistry, Pharmacology, Toxicology, and Biotechnology

Abstract

In this work, we explore the current knowledge about the phytochemistry and in vitro and in vivo evaluations of the extracts and, where appropriate, the main active components characterized and isolated from the Allamanda cathartica. Of the 15 Allamanda species, most phytochemical, pharmacological, and toxicological studies have focused on A. cathartica. These plants are used for the treatment of various health disorders. Numerous phytochemical investigations of plants from the A. cathartica have shown the presence of hydrocarbons, alcohols, esters, ethers, aldehydes, ketones, fatty acids, phospholipids, volatile compounds, phenolic compounds, flavonoids, alkaloids, steroids, terpenes, lactones, and carbohydrates. Various studies have confirmed that extracts and active substances isolated from the A. cathartica have multiple pharmacological activities. The species A. cathartica has emerged as a source of traditional medicine used for human health. Further studies on the phytochemical, pharmacological, and toxicological properties and their mechanisms of action, safety, and efficacy in the species of A. cathartica is recommended.

Predictive Chromatography of Leaf Extracts Through Encoded Environmental Forcing on Phytochemical Synthesis

“…In fact, these plants are listed under the Republic Act No. 8423 and by the Philippine Institute of Traditional and Alternative Health Care as recommended for use in treating specific physiological problems (Ammakiw and Odiem, 2013 ; Boy et al, 2018 ). An example of which is Blumea balsamifera (locally known and referred to hereafter as “sambong”), is a shrub that grows across Southeast Asia, India, and China, known for managing urolithiasis and other kidney problems (Ammakiw and Odiem, 2013 ; Montealegre and De Leon, 2017 ; Boy et al, 2018 ).…”

“…8423 and by the Philippine Institute of Traditional and Alternative Health Care as recommended for use in treating specific physiological problems (Ammakiw and Odiem, 2013 ; Boy et al, 2018 ). An example of which is Blumea balsamifera (locally known and referred to hereafter as “sambong”), is a shrub that grows across Southeast Asia, India, and China, known for managing urolithiasis and other kidney problems (Ammakiw and Odiem, 2013 ; Montealegre and De Leon, 2017 ; Boy et al, 2018 ). However, despite proven therapeutic effects, the herbal products derived from such medicinal plants remain difficult to commercialize because of the inconsistent use of extraction methods and the variable content in different batches of these herbal formulations (Sahoo et al, 2010 ; Carmona and Soares Pereira, 2013 ).…”

Antifungal activity of Allamanda polyantha seed extract and its iridoids promote morphological alterations in Cryptococcus spp.

“…These plants have been used in traditional medicine as antimicrobial, antiparasitic, anticancer, diuretic, and laxative, and to treat snake bites, among others. [ 15 ] Here, we evaluated the antifungal activity of an aqueous seed extract of Allamanda polyantha (Müll. Arg.…”

A Plumieridine-Rich Fraction From Allamanda polyantha Inhibits Chitinolytic Activity and Exhibits Antifungal Properties Against Cryptococcus neoformans

“…Included in this genus, Allamanda polyantha is endemic of the Brazilian Atlantic Forest ( Flora do Brasil, 2019 ). Plants of this genus are used in popular medicine to treat several illnesses, with potential antifungal, diuretic, antidiabetes and antiparasitic properties ( Petricevich and Abarca-Vargas, 2019 ). Several iridoid compounds have been isolated from Allamanda spp., especially from A. cathartica.…”

“…Several iridoid compounds have been isolated from Allamanda spp., especially from A. cathartica. The iridoids found in A. cathartica include, but are not limited to, plumiericin, isoplumiericin, plumieride, and plumieride coumarate ( Petricevich and Abarca-Vargas, 2019 ). However, the aglycone configuration of plumieride, plumieridine, has not been reported for the Allamanda spp.…”