Allantoin-loaded porous silica nanoparticles/polycaprolactone nanofiber composites: fabrication, characterization, and drug release properties

Abstract

The development of biocompatible nanocomposites for biomedical applications such as drug release has attracted increasing attention in recent years.

Improved shellac mediated nanoscale application drug release effect in a gastric-site drug delivery system

“…[1][2][3][4][5] As the nanotechnology has been developed during the decades with several historical breakthroughs, [6][7][8][9][10][11] numerous new applications have been applied to DDSs. [12][13][14] Nanoparticles and nanobers have been widely used in DDSs due to their popular and simple production methods. Drug delivery system characteristics are improved with the incorporation of biodegradable polymer carriers which sustain the release of encapsulated drugs and reduce the side effects.…”

Plant-derived silica nanoparticles and composites for biosensors, bioimaging, drug delivery and supercapacitors: a review

“…This material is also applicable for molecular imaging by T 2 -weighted magnetic resonance contrast influencing agents. Composites of rice husk-derived silica nanoparticles and polycaprolactone nanofibers are used for drug delivery of drugs such as allantoin (Ke et al 2016 ). To reduce cost and increase biocompatibility, 5-fluorouracil was fixed to chitosan-coated biomass silica nanoparticles (Dhinasekaran et al 2020 ).…”

Electrospinning: A promising technique for drug delivery systems

“…Silica nanoparticles have been very versatile to load different kinds of drugs and then embedded in electrospun polymers. These systems include PCL/silica nps with differents loaded drugs such as allantoin [57], levofloxacin [58], camptothecin [59], gentamicin [60]; also drug-loaded silica nanoparticles have been incorporated in Poly(L-Lactic acid) for doxorubicin release [61], poly(vinyl alcohol) for methylene blue release [62]. To incorporate drug-loaded silica nanoparticles into the electrospun matrix polymer is one of the main methods, but there are other systems of drug-loaded particles/polymer which are widely used in the electrospinning process, like bovine serum albumin (BSA) particles that were loaded with dexamethasone (DEX) and bone morphogenetic protein-2 (BMP-2) and then embedded in poly(caprolactone)-co-poly(ethylene glycol) copolymer, the dual-drug-loaded system was very effective to induce differentiation towards osteoblasts thanks to its synergistic effect of BMP-2 and DEX [63].…”