In this paper we study the effects of a protection zone Ω 0 for the prey on a diffusive predator-prey model with Holling type II response and no-flux boundary condition. We show the existence of a critical patch size described by the principal eigenvalue λ D 1 (Ω 0 ) of the Laplacian operator over Ω 0 with homogeneous Dirichlet boundary conditions. If the protection zone is over the critical patch size, i.e., if λ D 1 (Ω 0 ) is less than the prey growth rate, then the dynamics of the model is fundamentally changed from the usual predator-prey dynamics; in such a case, the prey population persists regardless of the growth rate of its predator, and if the predator is strong, then the two populations stabilize at a unique coexistence state. If the protection zone is below the critical patch size, then the dynamics of the model is qualitatively similar to the case without protection zone, but the chances of survival of the prey species increase with the size of the protection zone, as generally expected. Our mathematical approach is based on bifurcation theory, topological degree theory, the comparison principles for elliptic and parabolic equations, and various elliptic estimates.