Allele and genotype frequencies for primary hereditary cataract, multifocal retinopathy 1, and degenerative myelopathy in Pyrenean Mountain dog from Italy

Moretti, R.; Massimello, G.; Chessa, S.; Sartore, S.; Tranchero, A.; Profiti, M.; Sacchi, P.

doi:10.1016/j.tcam.2023.100844

Cited by 1 publication

(1 citation statement)

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“…Degenerative myelopathy (DM) is one of the most common chronic diseases of the spinal cord in dogs and has been known for more than 50 years [ 84 ]. The overall prevalence of the disease among all dogs is estimated at 0.19%, although due to its genetic origin, the prevalence varies widely among breeds and countries [ 85 , 86 , 87 , 88 ]. DM is an adult-onset (usually older than 8 years at the onset of clinical signs) chronic, progressive neurodegenerative disease with an autosomal recessive with incomplete penetrance mode of inheritance (OMIA 000263-9615), occurring primarily in large-breed dogs [ 87 ].…”

Section: Spinal Cord Diseasesmentioning

confidence: 99%

Common Neurologic Diseases in Geriatric Dogs

Espino,

Miño

2024

Animals

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The increase in the canine geriatric population means that veterinarians are more often confronted with diseases that are more prevalent in patients in this age group. As in other organ systems, degenerative, neoplastic, and vascular diseases are the most prevalent neurologic disorders in older dogs. A neurological disease in an older dog poses a challenge for the clinician due to the presence of concomitant diseases and age-related changes that make it difficult to interpret the neurological examination. In addition, given the age of the patients, some owners do not allow advanced imaging tests, and it is necessary to establish the most likely presumptive diagnosis to initiate treatment. Although many of these diseases can cause clinical signs that can be very upsetting, some of them can be managed with symptomatic therapy and have a good prognosis, such as idiopathic vestibular syndrome. Moreover, advances in and the greater availability of therapeutic options such as surgery and radiation therapy may increase survival and quality of life in diseases with a more serious prognosis, such as tumours. The aim of this review is to summarize the clinical presentation, diagnosis, and treatment of the more frequent diseases affecting the central nervous systems of geriatric dogs.

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