2023
DOI: 10.1101/2023.10.06.561245
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Allele biased transcription factor binding across human brain regions gives mechanistic insight into eQTLs

Belle A. Moyers,
Jacob M. Loupe,
Stephanie A. Felker
et al.

Abstract: SummaryTranscription Factors (TFs) influence gene expression by facilitating or disrupting the formation of transcription initiation machinery at particular genomic loci. Because genomic localization of TFs is in part driven by TF recognition of DNA sequence, variation in TF binding sites can disrupt TF-DNA associations and affect gene regulation. To identify variants that impact TF binding in human brain tissues, we quantified allele bias for 93 TFs analyzed with ChIP-seq experiments of multiple structural br… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Year Published

2024
2024
2024
2024

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
references
References 68 publications
(80 reference statements)
0
0
0
Order By: Relevance